Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-01-17
2006-01-17
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S309000, C544S310000, C544S311000, C544S314000
Reexamination Certificate
active
06987114
ABSTRACT:
The present invention relates to pyrimidinedione derivatives of following formula (I) which are useful as antiviral agents, especially as agents for treatment of AIDS, pharmaceutically acceptable salts thereof, process for the preparation thereof and pharmaceutical compositions containing the same, wherein R represents cyclopropyl; cyclobutyl; cyclohexyl; unsubstituted or mono-, di- or trisubstituted phenyl with a group selected from hydroxy, C1–C4alkyl, C1–C4alkoxy, halogen, trifluoromethyl, cyano and amino; 1- or 2-naphthyl; 9-anthracenyl; 2-anthraquinonyl; unsubstituted or substituted pyridyl with a group selected from C1–C4alkyl, C1–C4alkoxy, cyano and halogen; 2-, 3- or 4-quinolinyl; oxiranyl; 1-benzotriazolyl; 2-benzoxazolyl; furanyl substituted with C1–C4alkoxycarbonyl; C1–C4alkylcarbonyl; or benzoyl, R1represents halogen or C1–C4alkyl, R2and R3represent independently hydrogen or C1–C4alkyl, X represents oxygen atom, and Y represents oxygen atom, sulfur atom or carbonyl.
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Rajaratnam et al., “Synthesis and Anti-HIV Activity of Acyclic Unsaturated C6- and C5-Thiopenyl Uracil Nucleoside and Nucleotide Analogues,”Pharm. Pharmacol. Commun., 1998, pp. 205-209, vol. 4, No. 4.
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Cho Eui-Hwan
Chung Sun-Gan
Joo Jeong-Ho
Kwon Ho-Seok
Lee Jae-Eung
Birch & Stewart Kolasch & Birch, LLP
Rao Deepak
Samjin Pharmaceutical Co., Ltd
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