Antiviral pyrimidine nucleosides and methods for using same

Details Antiviral pyrimidine nucleosides and methods for using same Antiviral pyrimidine nucleosides and methods for using same

1994-04-14

1996-05-28

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 49, 514931, 514934, 536 41, 536 285, A61K 3170, C07G 300

Patent

active

055211631

ABSTRACT:
1'-Deoxy-5-ethyl-4'-thio-.beta.-uridine as a compound including its physiologically functional derivatives, pharmaceutical compositions containing it and methods of treating herpes virus infections are described.

REFERENCES:
patent: 5055457 (1991-10-01), Schrinner et al.
patent: 5159067 (1992-10-01), Schinazi et al.
patent: 5215970 (1993-06-01), Datema et al.
patent: 5356882 (1994-10-01), Walker et al.
European Patent Office Offical Action mailed on Jan. 28, 1994.
Huang et al: Nucleosides & Nucleotides, 1993, "A Facile Synthesis of 4'-thio-2'-deoxypyrimidine Nucleosides and Preliminary Studies on Their Properties," pp. 139-147.
J. Med. Chem. 1991, 34, pp. 2361-2366, "Synthesis and Biological Activity of 2'-Deoxy-4'-thio Pyrimidine Nucleosides.sup.1 " Secrest III et al.
J. Med. Chem. 1991, 34, pp. 2782-2786, "The Synthesis and Antiviral Activity of Some 4'-Thio-2'deoxy Nucleoside Analogues" Dyson et al.
J. Chem. Soc. Chem. Commun., 1991, pp. 741-742, "The Synthesis and Antiviral Properties of E-5-(2-Bromovinyl)-4'-thio-2'-deoxyuridine" Dyson et al.
J. Chem. Soc. Chem. Commun., 1991, pp. 1421-1422, "Stereocontrolled Preparation of Cyclic Xanthate; a Novel Synthetic Route etc." Uenishi et al.
J. Med. Chem., 1992, 35, pp. 533-538, "Synthesis and Anti-HIV Activity of 4'-Thio-2',3'-dideoxynucleosides" Secrist III et al.

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