Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1997-09-19
2000-05-09
Park, Hankyel
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
424 78, 424 7827, 424 7835, 526315, C12Q 170, A61K 3174, A61K 31785, C08F 1634
Patent
active
06060235&
ABSTRACT:
The present invention relates to a method of treating a viral infection in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer comprising a plurality of pendant hydrophobic groups and a plurality of pendant acid functional groups. The acid functional groups are connected directly to the polymer backbone or via an aliphatic spacer group of 1 to about 20 atoms in length.
REFERENCES:
patent: 3466365 (1969-09-01), Schlesinger
patent: 3624218 (1971-11-01), Regelson
patent: 3812248 (1974-05-01), Regelson
patent: 3859433 (1975-01-01), Regelson
patent: 3893890 (1975-07-01), Wurzburg et al.
patent: 3956480 (1976-05-01), Dichter et al.
patent: 3996347 (1976-12-01), Breslow et al.
patent: 4150238 (1979-04-01), Burg et al.
patent: 4223109 (1980-09-01), Wolgemuth
patent: 4361547 (1982-11-01), Sipos et al.
patent: 4604404 (1986-08-01), Munson, Jr. et al.
patent: 4762715 (1988-08-01), Lukas et al.
patent: 4783446 (1988-11-01), Neushul
patent: 5149523 (1992-09-01), Lundberg et al.
patent: 5152978 (1992-10-01), Baba et al.
patent: 5211944 (1993-05-01), Tempesta
patent: 5290894 (1994-03-01), Melrose et al.
patent: 5292505 (1994-03-01), Baba et al.
patent: 5308612 (1994-05-01), Lee
patent: 5346695 (1994-09-01), Nonoyama et al.
patent: 5424063 (1995-06-01), Cardin et al.
patent: 5510103 (1996-04-01), Yokoyama et al.
patent: 5571505 (1996-11-01), Cardin et al.
patent: 5670143 (1997-09-01), Cardin et al.
patent: 5670144 (1997-09-01), Cardin et al.
Leydet, A., et al., "Polyanion Inhibitors of Human Immunodeficiency Virus. Part IV. Polymerized Anionic Surfactants: Influence of the Density and Distribution of Anionic Groups on the Antiviral Activity," Bioorg. Med. Chem. Lett. (6):397-402 (1996).
Leydet, A., et al., "Polyanion Inhibitors of Human Immunodeficiency Virus and Other Viruses. 5. Telomerized Anionic Surfacants Derived from Amino Acids," J. Med. Chem. (40):342-349 (1997).
Leydet, A., et al., "Polyanion Inhibitors of Human Immunodeficiency Virus and Other Viruses. 6. Micelle-like Anti-HIV Polyanionic Compounds Based on a Carbohydrate Core," J. Med. Chem. (40):350-356 (1997).
Neyts, J. and De Clercq, E., "Effect of Polyanionic Compounds on Intracutaneous and Intravaginal Herpesvirus Infection in Mice: Impact on the Search for Vaginal Microbicides with Anti-HIV Activity," Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology (10):8-12 (1995).
Taylor, D.L., et al., "Novel Sulphonic Acid Polymers as Inhibitors of HIV Host-Cell Interactions," IXth Internat'l Conference on AIDS, Jun. 6-11, 1993, Abstract PO-B26-2071.
Baba, M., et al., "Pentosan polysulfate, a sulfated oligosaccharide, is a potent and selective anti-HIV agent in vitro," Antiviral Research (9):335-343 (1988).
Cushman, M., et al., "Preparation and Anti-HIV Activities of Aurintricarboxylic Acid Fractions and Analogues: Direct Correlation of Antiviral Potency with Molecular Weight," J. Med. Chem. (34):329-337 (1991).
Ito, M., et al., "Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro," Antiviral Research (7):361-367 (1987).
Leydet, A., et al., "Polyanion Inhibitors of Human Immunodeficiency Virus and Other Viruses. 1. Polymerized Anionic Surfactants," J. Med. Chem. (38):2433-2440 (1995).
Leydet, A., et al., "Polyanion Inhibitors of Human Immunodeficiency Virus and Other Viruses. Part 2. Polymerized Anionic Surfactants Derived from Amino Acids and Dipeptides," J. Med. Chem. (39):1626-1634 (1996).
Leydet, A., et al., "Polyanion inhibitors of human immunodeficiency virus. Part III. Polymerized anionic surfactants derived from D-glucose," Recl. Trav. Chim. Pays-Bas (115):421-426 (1996).
Mohan, P., et al., "Sulfonic acid polymers as a new class of human immunodeficiency virus inhibitors," Antiviral Research (18):139-150 (1992).
Tan, G.T., et al., "Sulfonic acid polymers are potent inhibitors of HIV-1 induced cytopathogenicity and the reverse transcriptases of both HIV-1 and HIV-2," Biochim. Biophys. Acta (1181):183-188 (1993).
Baba, M., et al., "Novel Sulfated Polymers as Highly Potent and Selective Inhibitors of Human Immunodeficiency Virus Replication and Giant Cell Formation," Antimicrob. Agents Chemother. 34(1):134-138 (1990).
Mandeville, III W. Harry
Neenan Thomas X.
GelTex Pharmaceuticals Inc.
Park Hankyel
LandOfFree
Antiviral polymers comprising acid functional groups and hydroph does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antiviral polymers comprising acid functional groups and hydroph, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antiviral polymers comprising acid functional groups and hydroph will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1063614