Antiviral phosphoramidates

Details Antiviral phosphoramidates Antiviral phosphoramidates

2006-08-11

2009-10-27

McIntosh, III, Traviss C (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S047000, C514S048000, C514S051000, C536S026100, C536S026800, C536S026900

Reexamination Certificate

active

07608599

ABSTRACT:
The invention provides novel nucleoside compounds of formula I wherein R1, R2a, R2b, R3, R4, R5R6, R8a, R9and R10are as defined herein which are useful for the treatment of Hepatitis C Virus (HCV) mediated diseases. The invention further provides methods for treatment or prophylaxis of HCV mediated diseases with compounds of formula I and pharmaceutical compositions comprising these compounds,

REFERENCES:
patent: 6846810 (2005-01-01), Martin et al.
patent: 2003/0236216 (2003-12-01), Devos et al.
patent: 2004/0121980 (2004-06-01), Martin et al.
patent: WO 9010012 (1990-09-01), None
patent: WO 01/18013 (2001-03-01), None
patent: WO 01/74827 (2001-10-01), None
patent: WO 02/100415 (2002-12-01), None
Curley, D., et al., “Synthesis and Anti-HIV Evaluation of some Phospamidate Derivatives of AZT,”Antiviral Res. (1990) vol. 14 pp. 345-356.
Gudmundsson, K., et al., “Phosphoramidate Protides of 2′,3′-Dideoxy-3′-fluoroadenosine and related Nucleosides with Potent Activity Against HIV and HBV, Nucleosides,”Nucleotides&Nucleic Acids(2003) vol. 22(10) pp. 1953-1961.
McGuigan, C., et al. “Synthesis and Evaluation of some novel phosphoramidate derivatives of 3′-azido-3′deoxythymidine (AZT) as anti-HIV Compounds,”Antiviral Chem.&Chemother. (1990) vol. 1(2) pp. 107-113.
McGuigan, C., et al. “Synthesis and anti-HIV Evaluation of some novel phosphoramidate derivatives of 3′-azido-3′deoxythymidine (AZT),”Antiviral Res. (1991) vol. 15(3) pp. 255-263.
McGuigan, C., et al. “Aryl phosphate derivatives of AZT retain activity against HIV1 in cell lines resistant to the action of AZT,”Antivir. Res. (1992) vol. 17(4) p. 311.
McGuigan, C., et al., “Intracellular Delivery of Bioactive AZT Nucleotides by Arl Phosphate Derivatives of AZT,”J. Med. Chem. (1993) vol. 36(8) p. 1048.
McGuigan, C., et al. “Synthesis and anti-HIV activity of some novel diaryl phosphate derivatives of AZT,”Antiviral Res. (1994) vol. 24 pp. 69-77.
McGuigan, C., et al., “Aryl Phosphoramidate Derivatives of d4T have Improved Anti-HIV Efficacy in tissue Culture and May Act by the Generation of a Novel intracellular Metabolite,”J. Med. Chem. (1996) vol. 39(8) p. 17848.
McGuigan, C., et al. “Application of Phosphoramidate Technology to Abacavir leads to Significant Enhancement of Antiviral Activity,”J. Med Chem. (2005) vol. 48 p. 3504.
Saboulard, D., et al. “Characterization of the Activation Pathway of Phosphoramidate Triester Prodrugs of Stavudine and Zidovudine,”Mol. Pharmacol. (1999) vol. 56 p. 693.
Siddiqui, A.D., et al. “The Presence of Substituents on the Aryl Moiety of the Aryl Phosphoramidate Derivative of d4T Enhances Anti-HIV Efficacy in Cell Culture,”J. Med Chem. (1999) vol. 42(3) p. 393.
Siddiqui, A.D., et al., “Stereospecific chemical and enzymatic stability of phosphoramidate triester prodrugs of d4T in vitro,”Eur. J. Pharm. Sci. (2004) vol. 22 p. 25.
Tobias,S.C. et. al., “Synthesis and Biological Studies of Novel Nucleoside Phosphoramidate Prodrug,”J. Med. Chem. (2001) vol. 44 pp. 4475-4480.
Wagner, C.R. et. al., “Pronucleotides: Towards the In Vivo Delivery of Antiviral and Anticancer Nucleotides,”Medicinal Research Reviews, NY, 2000, vol. 20 (6), pp. 417-450.

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