Antiviral peptides and means for treating herpes infections

Details Antiviral peptides and means for treating herpes infections Antiviral peptides and means for treating herpes infections

1987-05-07

1989-01-03

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 514 16, 530326, 530327, 530328, A61K 3702, C07K 706, C07K 708

Patent

active

047957409

ABSTRACT:
Disclosed herein are antiviral peptides of the formula A-R.sup.8 -R.sup.9 -R.sup.10 -R.sup.11 -R.sup.12 -R.sup.13 -R.sup.14 -R.sup.15 -B wherein A is from zero up to seven amino acid residues and includes a terminal hydrogen or a terminal N-acyl, or A is a phenylacetyl with optional substitution of the para position of the phenyl, R.sup.8, R.sup.9, R.sup.10, R.sup.13, R.sup.14 and R.sup.15 are various amino acid residues with the stipulation that one or more of the four amino acid residues immediately preceding R.sup.11 may optionally be deleted, R.sup.11 and R.sup.12 are independently Val, D-Val, Nva, D-Nva, Leu, D-Leu, Nle, D-Nle, Ile or D-Ile, and B is hydroxy, amino or lower alkylamino. The antiviral activity of the peptides can be enhanced by combining them with a protease inhibitor. The peptides and the combination are useful for the treatment of herpes viral infections in mammals.

REFERENCES:
The Journal of Biological Chem., 262, No. 26 (1987), 12413-12416.
P. W. Choppin et al., J. Infect. Dis., 143, 352 (1981).
P. W. Choppin et al., "Targets for the Design of Antiviral Agents"; E. De Clercq and R. T. Walker, eds., Plenum Press, New York, 1984, pp. 287-305.
A. Alarcon et al., Antiviral Research, 4, 231 (1984).
B. M. Dutia et al., Nature 321, 439 (1986).
E. A. Cohen et al., Nature 321, 441 (1986).
E. A. Cohen et al., J. Virol., 60, 1130 (1986).

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