Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 8 to 10 amino acid residues in defined sequence
Patent
1988-09-15
1991-11-19
Lee, Mary C.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
8 to 10 amino acid residues in defined sequence
530329, 530330, C07K 706
Patent
active
050667831
ABSTRACT:
Disclosed herein are antiviral peptides of the formula A-R.sup.8 -R.sup.9 -R.sup.10 -R.sup.11 -R.sup.12 -R.sup.13 -R.sup.14 -R.sup.15 B wherein A is from zero up to seven amino acid residues and includes a terminal hydrogen or a terminal N-acyl, or A is a phenylpropionyl with optional substitution of the para position of the phenyl, R.sup.8, R.sup.9, R.sup.10, R.sup.13, R.sup.14 and R.sup.15 are various amino acid residues with the stipulation that one or more of the three amino acid residues immediately preceeding R.sup.11 and R.sup.12 are independently Val, D-Val, Nva, D-Nva, Leu, D-Leu, Nle, D-Nle, Ile or D-Ile, and B is hydroxy, amino or lower alkylamino. The antiviral activity of the peptides can be enhanced by combining them with a protease inhibitor. The peptides and the combination are useful for the treatment of herpes viral infections in mammals.
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B. M. Dutia, H. S. Marsden et al., Nature 321, 439-441 (1986).
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Kitada et al., Pept. Chem. 22: 43-8 (1985) Chemical Abstract 103, 215768n.
Brazeau Paul
Cohen Eric A.
Gaudreau Pierrette
Langelier Yves
Michaud Jacques
Ambrose Michael G.
Lee Mary C.
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