Antiviral peptides

Details Antiviral peptides Antiviral peptides

1991-05-21

1992-04-14

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530328, A61K 3702, C07K 706

Patent

active

051048540

ABSTRACT:
Novel antiviral peptides are disclosed which have a sequence of about 6 to 30 amino acids and which are substantially identical to a small portion of a glycoprotein in a virus that contains a lipid-bilayer in its structure. A preferred peptide having antiviral activity against influenza virus is the decapeptide amide N-G-S-L-Q-C-R-I-C-I-NH.sub.2 [SEQ ID NO:3].

REFERENCES:
patent: 5026686 (1991-06-01), Schlesinger et al.
Cohen, Science 205, 964-971 (1979).
Dolin, Science 227, 1296-1301 (1985).
Robins, Chem. & Eng. News 64, 28-40 (1986).
Hirsch & Kaplan, Scient. Amer. 256(4), 76-85 (1987).
Varmus, Science 240, 1427-1435 (1988).
Strauss et al., Virology 132, 92-110 (1984).
Schlesinger & Schlesinger, The Togaviridae and Flaviviridae, Plenium Press, N.Y. 1986, pp. 35-43.
Schlesinger & Cahill, Virology, 168, 187-190 (1989).
Hiti et al., Virology, 111, pp. 113-124 (1981).

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