Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-01-29
1997-09-30
Geist, Gary
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549389, A61K 3144, C07D31192
Patent
active
056726074
ABSTRACT:
The present invention provides novel antiviral naphthoquinone compounds, which may be isolated from plants of the genus Conospermum or synthesized chemically, in accordance with the present inventive methods. The antiviral naphthoquionone compounds, derivatives thereof, and prodrugs thereof, may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.
REFERENCES:
Decosterd, "HIV Inhibitory Natural Products . . . ", J Am Chem Soc, 115(15), 6673-9, 1992.
Singh et al., The Journal of Antibiotics, 38, 706-712 (1985).
Boyd, in AIDS Etiology, Diagnosis, Treatment and Prevention (DeVita et al., eds.), 305-319 (Philadelphia: Lippincott, 1988).
Cameron et al., Aust. J. Chem., 31, 1323-1333 (1978).
Cannon et al., Tetrahedron Lett., 32, 2795-2798 (1975).
Durley et al., J. Chem. Soc. Perkin I, 153-169 (1975).
Gulakowski et al., J. Virol. Methods, 33, 87-100 (1991).
Gustafson et al., J. Med. Chem., 35, 1978-1986 (1992).
Jeffreys et al., Tetrahedron Lett., 24, 1085-1088 (1983).
Jurd, Aust. J. Chem., 33, 1603-1610 (1980).
McCaffrey et al., In Vitro Cell Develop. Biol., 24, 247-252 (1988).
Rink et al., J. Cell. Biol., 95, 189-196 (1982).
Shih et al., PNAS, 88, 9878-9882 (1991).
Waterman et al., J. Chem. Res. (M), 101-144 (1985).
Weislow et al., J. Natl. Cancer Inst., 81 (8), 577-586 (1989).
White et al., Antiviral Research, 16, 257-266 (1991).
Boyd Michael R.
Cardellina, II John H.
Cragg Gordon M.
Decosterd Laurent A.
Gustafson Kirk R.
Geist Gary
Scalzo Catherine
The United States of America as represented by the Department of
LandOfFree
Antiviral naphthoquinone compounds, compositions and uses thereo does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antiviral naphthoquinone compounds, compositions and uses thereo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antiviral naphthoquinone compounds, compositions and uses thereo will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2256808