Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdin

Details Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdin Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdin

1987-12-21

1989-11-14

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 45, 514 46, 514 47, 536 27, A61K 31665, A61K 3167

Patent

active

048807842

ABSTRACT:
Compounds of the structure: ##STR1## wherein R.sub.1 and R.sub.2 individually are H or C.sub.1 -C.sub.18 acyl and R.sub.3 is H, C.sub.1 -C.sub.18 acyl or ##STR2## or R.sub.1 is H and together R.sub.2 and R.sub.3 are ##STR3## and X is .dbd.O or .dbd.S, Y is --OH, --SH, --NH.sub.2 or halogen, and Z is H, --NH.sub.2, --OH or halogen, wherein halogen is Cl or Br, or a pharmaceutically acceptable salt thereof are useful as antivirals, antitumors and as immune system enhancers.

REFERENCES:
patent: 3277093 (1966-10-01), Schroeder
patent: 3660405 (1972-05-01), Berger et al.
patent: 4309419 (1982-01-01), Wolberg et al.
patent: 4539205 (1985-09-01), Goodman
patent: 4643992 (1987-02-01), Goodman
patent: 4746651 (1988-05-01), Goodman
Kochetkov et al., "Organic Chemistry of Nucleic Acids", Part B, Plenum Press, New York, 1972, pp. 449-465.

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