Antiviral method, agents and apparatus

Surgery – Blood drawn and replaced or treated and returned to body

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514274, 435236, 435238, 604 5, 604416, A61M 3700, C12N 706

Patent

active

049156837

ABSTRACT:
A method of treating a body fluid which is to be infused so as to inactivate any enveloped viruses in said fluid comprises mixing the body fluid with an effective amount of a photosensitizing agent which will bind to the viruses and/or virus infected cells and photosensitize them, and then exposing the resulting mixture to visible light to excite and inactivate the viruses. An apparatus for use in the method includes at least one container which contains an effective amount of the photosensitizing agent and which has at least one wall which is permeable to visible light. A number of photosensitizing agents which can be used in the method also are disclosed.

REFERENCES:
patent: 3110308 (1963-11-01), Bellamy Jr.
patent: 3140716 (1964-07-01), Harrison et al.
patent: 4321919 (1982-03-01), Edelson
patent: 4398906 (1983-08-01), Edelson
patent: 4424201 (1984-01-01), Valinsky et al.
patent: 4428744 (1984-01-01), Edelson
patent: 4464166 (1984-08-01), Edelson
patent: 4568328 (1986-02-01), King
patent: 4573960 (1986-03-01), Goss
patent: 4573961 (1986-03-01), King
patent: 4573962 (1986-03-01), Troutner
patent: 4578056 (1986-03-01), King et al.
patent: 4596547 (1986-06-01), Troutner
patent: 4623328 (1986-11-01), Hartranft
patent: 4727027 (1988-02-01), Wiesehann
patent: 4748120 (1988-05-01), Wiesehahn
patent: 4775625 (1988-10-01), Sieber
Sieber et al., Abstract "Antiviral Activity of Merocyanine 540", dated Feb. 15-19, 1987.
O'Brien J. M., Schober S. L., Burns W. H., Krueger G. J., Montgomery R. R., Sieber F: Inactivation of Enveloped Human Pathogenic Viruses by Merocyanine 540-Mediated Photosensitization and its Potential Use in Blood Product Sterilization. Blood 70:333a, 1987 (abstract).
Sieber F., Krueger G. J., O'Brien J. M., Schober S. L ., Sensenbrenner L. L., Sharkis SJ: Inactivation of Friend Erythroleukemia Virus and Friend Virus-Transformed Cells by Merocyanine 540-Mediated Photosensitization. Blood 73:345-350, 1989.
Journal of Cellular Physiology, 116: 118-124 (1983), "Susceptibility to Merocyanine 540-Mediated Photosensitization: A Differentiation Marker on Murine Hematopoietic Progenitor Cells", Richard C. Meagher, Fritz Sieber, and Jerry L. Spivak.
Proc. Natl. Acad. Sci. USA, vol. 81, pp. 7584-7587, Dec. 1984, Medical Sciences, "Selective Killing of Leukemic Cells by Merocyanine 540-Mediated Photosensitization", Fritz Sieber, Jerry L. Spivak, and Alison M. Sutcliffe.
Molecular Basis of Cancer, Part B: Macromolecular Recognition, Chemotherapy, and Immunology, pp. 227-234, 1985, Alan R. Liss, Inc., "Merocyanine 540-Mediated Photosensitization of Leukemia and Solid Tumor Cells", Fritz Sieber.
Cancer Research 46, pp. 2072-2076, Apr. 1986, "Dye-Mediated Photosensitization of Murine Neuroblastoma Cells", Fritz Sieber and Maya Sieber-Blum.
Blood, vol. 68, No. 1 (Jul.) 1986, pp. 32-36, "Dye-Mediated Photolysis of Human Neuroblastoma Cells: Implications for Autologous Bone Marrow Transplantation", Fritz Sieber, Sanjay Rao, Scott D. Rowley, and Maya Sieber-Blum.
Minimal Residual Disease in Acute Leukemia, 1986, A. Hagenbeek, B. Lowenberg (editors), Martinus Nijhoff Publishers, "Detection and Selective Destruction of Tumor Cells by the Lipophilic Dye", Merocyanine 540, pp. 282-294, Fritz Sieber.
Transfusion, vol. 26, No. 5, 1986, pp. 481-483, "Inactivation of Human T-Cell Lymphotropic Virus, Type III by Heat, Chemicals, and Irradiation", Gerald V. Quinnan, Jr., Martha A. Wells, Alec E. Wittek, Michael A. Phelan, Ronald E. Mayner, Stephen Feinstone, Robert H. Purcell and Jay S. Epstein.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antiviral method, agents and apparatus does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antiviral method, agents and apparatus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antiviral method, agents and apparatus will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2297188

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.