Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1995-04-19
1998-02-17
Naff, David M.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424 946, 424 9461, 424 9463, 435174, 435177, 435236, 436528, 514 44, A61K 9127, A61K 3846, C12N 1100, C12N 704
Patent
active
057189153
ABSTRACT:
Complexes are prepared containing two or more different effector molecules joined to each other by a joining component. At least one of the effector molecules can bind to a target molecule and at least one of the other effector molecules has therapeutic properties. The joining component can be liposomes, proteins and organic polymers including dendrimer polymers, and can be of sufficient length and/or flexibility to permit the therapeutic effector molecule to interact with a target at the same time as the binding molecules. An antiviral liposome is prepared by coupling to a liposome outer surface a hydrolytic enzyme capable of digesting a viral component and a target-binding moiety which may be a polypeptide, glycoprotein or glycoprotein fragment having specificity for viruses such as HIV-1, influenza virus and hepatitis virus. The hydrolytic enzyme may be a glycosidase, phospholipase, lipase, cholesterol esterase, nuclease or protease. A second hydrolytic enzyme and target-binding moiety may also be present, and albumin may be coupled to the liposome surface. Within the liposome may be an internal hydrolytic enzyme capable of digesting a viral component.
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Virtanen Jorma
Virtanen Sinikka
Burstein Laboratories, Inc.
Naff David M.
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