Antiviral isothiosemicarbazones

Details Antiviral isothiosemicarbazones Antiviral isothiosemicarbazones

1983-03-04

1986-07-01

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

A61K 31155, A01N 3752

Patent

active

045980950

ABSTRACT:
An antiviral drug contains as its effective component an isothiosemicarbazone represented by the following general formula (I) or an acidic salt thereof: ##STR1## wherein R.sub.1 represents a halogen atom, a lower (C.sub.1 -C.sub.6) alkyl group, a hydroxy group, a phenyl group which may be or may not be substituted with an alkoxy group containing 1 to 12 carbon atoms, or an unsubstituted or substituted phenylethynyl group represented by the following general formula (II): ##STR2## (wherein R.sub.5 and R.sub.6 may be the same or different, and they each represent a hydrogen atom, a halogen atom, a lower (C.sub.1 -C.sub.6) alkyl group, a hydroxy group or an alkoxy group containing 1 to 12 carbon atoms); R.sub.2 represents a hydrogen atom or a lower (C.sub.1 -C.sub.6) alkyl group; R.sub.3 represents a lower (C.sub.1 -C.sub.6) alkyl group or a benzyl group; R.sub.4 represents a hydrogen atom or a lower (C.sub.1 -C.sub.6) alkyl group. Many of these effective component compounds not only have antiviral activity (especially against influenza virus), but also prevent the breeding of and exterminate plant pathogenic molds.

REFERENCES:
Asahi, "Polarography of Thioacetazone and its Related Compounds", Chem. Pharm. Bull. Japan, 11:930-938 (1963).
Toku et al, "Synthesis and Antimicrobial Activities of Isothiosemicarbazones", J. Antibact. Antifung. Agents, 9(12): 551-561 (1981), Bokin Bobai.
Chem. Abstracts, vol. 96: 162266a (1982).
Index Chemicus II, No. 33019 (1963).
Nishimura et al, "Antiviral Compounds, VII, Synthesis and Anti-influenza VVirus Activity of Alkoxyacetophenone Amidinohydrazones", Kitasato Arch. of Exp. Med. 48: 125-130 (1975).
Nishimura et al, "Antiviral Compounds, VI, Synthesis and Anti-influenza Virus Activity of Alkoxybenzyalacetone Amidinohydrazones", Kitasato Arch. of Exp. Med. 48: 23-30 (1975).
Nishimura et al, "Antiviral Compounds, IX, Synthesis and Anti-influenza Virus Activity of Bis-Amidinohydrazones of Glyoxal and Methylglyoxal, " Kitasato Arch. of Exp. Med. 48(4): 171-181 (1975).
Hirai et al, "Effect of Thiosemicarbazones on the Multiplication of Tobacco Mosaic Virus", Nature 181: 352-353 (1958).
Nishimura et al, "Antibacterial Activities of Amidinohydrazones of Benzalacetones, Cinnamaldehydes, Acetophenones and Benzaldehydes", Kitasato Arch. of Exp. Med., 46: 43-81 (1973).
Nishimura et al, "Antiviral Compounds, XII, Antiviral Activity of Amidinohydrazones of Alkoxyphenyl-substituted Carbonyl Compounds Against Influenza Virus in Eggs and in Mice", Kitasato Arch. of Exp. Med., 50: 39-46 (1977).
Nishimura et al, "Antiviral Compounds, VIII, Synthesis and Anti-influenza Virus Activity of Amidinohydrazones of Alkoxybenzaldehydes and Alkoxycinnamaldehydes", Kitasato Arch. of Exp. Med., 48(4): 165-170 (1975).

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