Antiviral guanine analogs

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 45, 514266, 514300, 514301, 514302, 514 81, 536 2714, 536 2761, 536 2762, 536 2763, 536 277, 536 278, 536 2781, 544258, 544244, 546113, 546114, 546116, 546 23, A61K 31505

Patent

active

054460450

ABSTRACT:
A series of guanine analogs having the basic structures of ##STR1## and physiological salts thereof. Also disclosed are a variety of the use of the compounds as a composition with a physiological carrier or in combination therapy with acyclovir, HBG and ganciclovir in the treatment of viral disease.

REFERENCES:
patent: 4746651 (1988-05-01), Goodman
patent: 4880784 (1989-11-01), Robins et al.
patent: 5166141 (1992-11-01), Goodman et al.
Bhattacharya et al. Chem. Abstr. vol. 121 entry 8983 (1994).
W. Ashton, et al., "Synthesis and Antiherpetic Activity of (.+-.)-9-[[(Z)-2-(hydroxymethyl)cyclopropyl]methyl]guanine and Related Compounds" J. Med. Chem. 31:2304-2315 (1988).
E. Badawey, et al., "Potential anti-microbials, I. Synthesis and structure-activity studies of some new thiazolo[4,5-d]pyrimidine derivatives" Eur. J. Med. Chem. 28:91-96 (1993).
E. Badawey, et al., "Potential anti-microbials. II. Synthesis and in vitro anti-microbial evaluation of some thiazolo[4,5-d]pyrimidines" Eur. J. Med. Chem. 28:97-101 (1993).
J. Baker, et al., "Synthesis of Derivatives of Thiazolo[4,5-d]pyrimidine, Part I." J. Chem. Soc. pp. 603-606 (1969).
J. Baker, et al., "Synthesis of Derivatives of Thiazolo[4,5-d]pyrimidine, Part II." J. Chem. Soc. pp. 2478-2484 (1970).
B. Bhattacharya, et al., "Synthesis of Certain N- and C-Alkyl Purine Analogs." J. Het. Chem. vol. 30, No. 5 pp. 1341-1349 (Oct.-Nov. 1993).
P. Bonnet, et al., "Modulation of Leukocyte Genetic Expression by Novel Purine Nucleoside Analogues. A New Approach to Antitumor and Antiviral Agents" Journal of Medicinal Chemistry 36:635-653 (1993).
D. Borcherding, "Potential Inhibitors of S-Adenosylmethionine-Dependent Methyltransferases. II. Molecular Dissections of Neplanocin A as Potential Inhibitors of S-Adenosylhomocysteine Hydrolase" J. Med. Chem. 31:1729-1738 (1988).
C. Chu, et al., "Chemistry and Antiviral Activities of Acyclonucleosides" J. Heterocyclic Chem. 23:289-319 (1986).
J. Colacino, et al., "Antiviral Activity of 2'-2'-Fluoro-.beta.-D-Arabinofuranosyl-5-Iodocytosine Against Human Cytomegalovirus in Human Skin Fibroblasts" Antimicrobial Agents and Chemotherapy 28:252-258 (1985).
D. Haines, et al., "Synthesis and Biological Activity of Unsaturated Carboacyclic Purine Nucleoside Analogues" J. Med. Chem. 30:943-947 (1987).
M. Harnden, et al., "Novel Acyclonucleotides: Synthesis and Antiviral Activity of Alkenylphosphonic Acid Derivatives of Purines and a Pyrimidine" J. Med. Chem. 36:1343-1355 (1993).
S. Hayashi, et al., "Adenallene and cytallene: Acyclic nucleoside analogues that inhibit replication and cytopathic effect of human immunodeficiency virus in vitro" Proc. Natl. Acad. Sci. USA 85:6127-6131 (1988).
P. Herdewijn, "Novel nucleoside strategies for anti-HIV and anti-HSV therapy" Antiviral Research 19:1-14 (1992).
A. Katritzky, et al., "The Preparation of Symmetrical Secondary Alkyl Bromides" Chemica Scripta 27:477-478 (1987).
G. Kini, et al., "Synthesis and Antiviral Activity of Certain Guanosine Analogues in the Thiazolo[4,5-d]pyrimidine Ring System" J. Med. Chem. 34:3006-3010 (1991).
A. Larsson, et al., "Mode of Action, Toxicity, Pharmacokinetics, and Efficacy of Some New Antiherpesvirus Guanosine Analogs Related to Buciclovir" Antimicrobial Agents and Chemotherapy 30:598-605 (1986).
C. Lopez, et al., "2'-Fluoro-5-Iodo-Aracytosine, a Potent and Selective Anti-Herpesvirus Agent" Antimicrobial Agents and Chemotherapy 17:803-806 (1980).
S. Megati, et al., "Unsaturated Phosphonates as Acyclic Nucleotide Analogues. Anomalous Michaelis-Arbuzov and Michaelis-Becker Reactions with Multiple Bond Systems" J. Org. Chem. 57:2320-2327 (1992).
M. Michael, et al., "Alkylpurines as Immunepotentiating Agents. Synthesis and Antiviral Activity of Certain Alkylguanines" J. Med. Chem. 36:3421-3436 (1993).
K. Nagahara, et al., "Thiazolo[4,5-d]prymidine Nucleosides. The Synthesis of Certain 3-.beta.-D-Ribofuranosylthiazolo[4,5-d]pyrimidines as Potential Immunotherapeutic Agents" J. Med. Chem. 33:407-415 (1990).
S. Phadtare, et al., "Nucleic Acid Derived Allenols: Unusual Analogues of Nucleosides and Antiretroviral Activity" J. Am. Chem. Soc. 111:5925-5931 (1989).
S. Phadtare, et al., "Synthesis and Biological Properties of 9-(trans-4-Hydroxy-2-buten-1-yl)adenine and Guanine: Open-Chain Analogues of Neplanocin A" J. Med. Chem. 30:437-440 (1987).
S. Phadtare, et al., "Unsaturated and Carbocyclic Nucleoside Analogues: Synthesis, Antitumor, and Antiviral Activity" J. Med. Chem. 34:421-429 (1991).
M. Robins, et al., "Nucleic acid related compounds. 37. Convenient and high-yield syntheses of N-[2-hydroxyethoxy)methyl]heterocycles as acrylic nucleoside analogues" Can. J. Chem. 60:547-553 (1982).
C. Tann, et al., "Fluorocarbohydrates in Synthesis. An Efficient Synthesis of 1-(2-Deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-iodouracil (.beta.-FIAU) and 1-(2-Deoxy-2-fluoro-.beta.-D-arabinofuranosyl)thymine (.beta.-FMAU)" J. Org. Chem. 50:3644-3647 (1985).
I. Verheggen, et al., "Synthesis and Antiherpes Virus Activity of 1,5-Anhydrohexitol Nucleosides" J. Med. Chem. 36:2033-2040 (1993).
K. Watanabe, et al., "Nucleosides. 110. Synthesis and Antiherpes Virus Activity of Some 2'-Fluoro-2'-deoxyarabinofuranosylpyrimidine Nucleosides" Journal of Medicinal Chemistry 22:21-24 (1979).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antiviral guanine analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antiviral guanine analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antiviral guanine analogs will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1819596

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.