Antiviral ethers of aspartate protease substrate isosteres

Details Antiviral ethers of aspartate protease substrate isosteres Antiviral ethers of aspartate protease substrate isosteres

1998-08-21

1999-08-10

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546291, A61K 3144, C07D21365

Patent

active

059359765

ABSTRACT:
Antiretroviral compounds (which are effective, for example, against HIV) of the formula I ##STR1## in which R.sub.1 is an acyl radical lower-alkoxy-lower-alkanoyl whose lower alkoxy radical is unsubstituted or is substituted by halogen, phenyl, lower alkoxy or a heterocyclic radical selected from piperidinyl, pyrrolidinyl, tetrahydropyranyl, tetrahydrofuranyl, thiazolidinyl, thiazolyl, indolyl or 4H-1-benzopyranyl which is unsubstituted or substituted by oxo, hydroxyl, amino, lower alkyl, lower-alkoxycarbonyl and/or phenyl-lower-alkoxycarbonyl; lower alkanoyl which is unsubstituted or is substituted by one of the said unsubstituted or substituted heterocyclic radicals; arylcarbonyl or heterocyclylcarbonyl which are substituted by heterocyclyl or heterocyclyl-lower-alkyl; phenyl-lower-alkanoyl which is substituted by hydroxyl and lower alkyl; or arylsulfonyl;

REFERENCES:
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patent: 5304532 (1994-04-01), Munro et al.
patent: 5643878 (1997-07-01), Bold et al.
patent: 5753652 (1998-05-01), Fassler et al.
Rich et al., J. Med, Chem. vol. 34, pp. 1225-1228 (1991).
deSolms et al., J. Med. Chem., vol. 34, 2852-2857 (1991).

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