Antiviral dendrimers

Details Antiviral dendrimers Antiviral dendrimers

1997-04-28

2001-02-20

Webman, Edward J. (Department: 1617)

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Aftertreated polymer

C424S078270, C424S078290, C424SDIG001, C525S512000, C525S513000, C525S514000

Reexamination Certificate

active

06190650

ABSTRACT:

FIELD OF THE INVENTION
This invention relates to antiviral agents, and in particular it relates to dendrimers which have been found to have significant antiviral activity against human immunodeficiency virus (HIV) and other enveloped viruses.
BACKGROUND OF THE INVENTION
It has been established that certain sulfonated polysaccharide compounds have antiviral activity when screened against HIV, however these compounds are relatively unstable and accordingly large amounts of these compounds are required to obtain effective antiviral effects. In addition, many of these compounds, including heparin and dextran sulfate for example, are potent anticoagulants and because of this activity they are not particularly suited for clinical use as antiviral agents.
The present invention provides a new class of antiviral agents based on a particular type of polymer referred to herein as a “dendrimer”, which have substantial antiviral activity against HIV1 and HIV2, CMV and HSV, and which have substantially no anticoagulant activity. These compounds are therefore well suited for prophylactic and therapeutic use as antiviral agents in humans.
SUMMARY OF THE INVENTION
According to the present invention, there is provided an antiviral compound comprising a dendrimer having a plurality of terminal groups wherein at least one of said terminal groups has an anionic- or cationic-containing moiety, other than a 2-thiosialic acid moiety, bonded thereto.
Such a dendrimer is referred to here in as an “anionic or cationic dendrimer”, and this term is used throughout this specification and the claims which follow to include not only the dendrimers per se, but also their pharmaceutically or veterinarily acceptable salts, for example the alkaline metal or alkaline earth metal salts such as the sodium, potassium or calcium salts.


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Roy Rene et al., “Solid-Phase Synthesis of Dendritic Sialoside Inhibitor of Influenza A Virus Hemagglutinin,” Journal of the Chemical Society, Chemical Communications, 24: 1869-1872 (1993).

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