Antiviral compounds and antihypertensive compounds

Details Antiviral compounds and antihypertensive compounds Antiviral compounds and antihypertensive compounds

1992-02-05

1992-12-29

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Silicon containing doai

514312, 514 82, 514432, 514456, 514682, 546 14, 546155, 546 23, 546153, 544128, 544198, 544238, 544405, 549214, 549283, 549 23, 5483114, 5483451, C07D21556

Patent

active

051751518

ABSTRACT:
Compounds useful as antihypertensive agents, or antiviral agents against DNA containing viruses, such as herpes group viruses, are disclosed. The compounds are represented by Formula 1.0: ##STR1## and their pharmaceutically acceptable salts and solvates. Pharmaceutical compositions containing compounds represented by Formula 1.0 are disclosed. Also disclosed are methods of treating hypertension or a viral infection using compounds represented by Formulas 1.0.
Also disclosed is a compound of Structure B ##STR2## useful as an intermediate in producing compounds of Formula 1.0. A process for preparing the compounds of Formula 1.0 is also disclosed. In the process a compound of Structure B ##STR3## is reacted with an alkoxide R.sub.1 O.sup.- M.sup.+ in a solvent comprising the corresponding alcohol R.sub.1 OH of the alkoxide. Optionally, an organic cosolvent may be used with the solvent.

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Derwent Abstract J90005-752-B.
Derwent Abstract J89035-827-B.

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