Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-03-05
1994-06-07
Tsang, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514261, 514262, 544265, 544276, 544277, 544317, A61K 31505, C07D23902
Patent
active
053189744
ABSTRACT:
The present invention relates to amino acid esters of pyrimidine and purine nucleosides containing an acyclic side chain, and their use in medical therapy, particularly the treatment of herpes virus infections. Also provided are pharmaceutical formulations and processes for the preparation of compounds according to the invention.
REFERENCES:
patent: 4221794 (1980-09-01), Simon et al.
patent: 4221910 (1980-09-01), Giner-Sorolla
patent: 4548819 (1985-10-01), DeClercq et al.
patent: 4567182 (1986-01-01), Farraris
patent: 4868187 (1989-09-01), Ogilvie
patent: 4957924 (1990-09-01), Beauchamp
patent: 5017701 (1991-05-01), Grinter et al.
patent: 5036071 (1991-07-01), Johansson et al.
patent: 5059604 (1991-10-01), Krenitsky et al.
patent: 5061708 (1991-10-01), Krenitsky
patent: 5138057 (1992-08-01), Green et al.
Journ. of Med. Chem.; vol. 25; No. 4; Apr. 1983; pp. 602-604; American Chemical Society; Columbus, Ohio; US: L. Colla et al.
"Synthesis and antiviral activity of water-soluble esters of acyclovir".
Biochemistry, vol. 12; No. 25; 1973; pp. 5135-5138; Stansilav Chladek et al.; "Phenylalanine esters of open-chain analog of adenosine as substrates for ribosomal peptidyl transferase".
Arc Ophalmol; vol. 102; Jan. 1982; pp. 140-142; Prabhat C. Maudgal, MD et al.; "Topical treatment of experimental herpes simplex keratouveitis with 2'-O-glycyclacyclovir; A water-soluble ester of acyclovir".
Helvetica Chimica Acta; vol. 70; 1987; pp. 219-231; Gholam H. Hakimelahi, et al.; Ring-open analogues of adenine nucleoside. aminoacyl derivatives of cyclo-and acyclo-nucleosides.
European search report on the corresponding foreign application (received by counsel on Dec. 14, 1992) with art citations all listed as (Technical background) or P(intermediate document).
Search Topic: Pre-1989 references; Database searched: Chemical Abstracts; Dates covered: 1967-Sep. 5, 1992.
Brown Donald
Burroughs Wellcome Co.
Green Hannah O.
Nielsen Lawrence A.
Tsang Cecilia
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