Antiviral compounds

Details Antiviral compounds Antiviral compounds

1995-11-30

1998-01-13

Guzo, David

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

514183, C12N 500, A01N 4372, A01N 4390

Patent

active

057078670

ABSTRACT:
The macrolide FK506, produced by Fujisawa Pharmaceuticals is effective in inhibiting the replication of hepatitis D virus. It is believed that replication is inhibited either by virtue of the ability of FK506 to inhibit proline isomerase or otherwise to interfere with the function of a C-terminal proline in a replication factor or by virtue of its interference with RNA replication directly.

REFERENCES:
patent: 5196437 (1993-03-01), Starzl et al.
patent: 5238689 (1993-08-01), Dwyer et al.
patent: 5308847 (1994-05-01), Calne
Bartz, S.R. et al., "Inhibition of human immunodeficiency virus replication by nonimmunosuppressive analogs of cyclosporin A," Proc. Natl. Acad. Sci. USA 92:5381-5385 (Jun. 1995).
Billich, A. et al., "Mode of Action of SDZ NIM 811, a Nonimmunosuppressive Cyclosporin A Analog with Activity against Human Immunodeficiency Virus (HIV) Type 1: Interference with HIV Protein-Cyclophilin A Interactions," Journal of Virology 69(4):2451-2461 (Apr. 1995).
Cote, P.J. et al., "Cyclosporin A Modulates the Course of Woodchuck Hepatitis Virus Infection and Induces Chronicity," The Journal of Immunology 146(9):3138-3144 (May 1, 1991).
Damaso, C.R.A. et al., "Cyclosporin A inhibits vaccinia virus replication in vitro," Arch Virol 134:303-319 (1994).
Glenn, J.S. et al., "In Vitro-Synthesized Hepatitis Delta Virus RNA Initiates Genome Replication in Cultured Cells," Journal of Virology (1990) 64(6):3104-3107.
Glenn, J.S. et al., "Trans-Dominant Inhibition of Human Hepatitis Delta Virus Genome Replication," Journal of Virology (1991) 65(5):2357-2361.
Gruber, A. et al., "Reactivation of chronic hepatitis C after withdrawal of immunosuppressive therapy," Journal of Internal Medicine 234:223-225 (1993).
Karpas, A. et al., "Inhibition of human immunodeficiency virus and growth of infected T cells by the immunosuppressive drugs cyclosporin A and FK 506," Proc. Natl. Acad. Sci. USA 89:8351-8355 (Sep. 1992).
Kondo, Y. et al., "Effect of Hexamethylene Bisacetamide and Cyclosporin A on Recovery of Herpes Simplex Virus Type 2 form the in Vitro Model of Latency in a Human Neuroblastoma Cell Line," Cancer Research 50:7852-7857 (Dec. 15, 1990).
Lykavieris, P. et al., "HBV Infection in Pediatric Liver Transplantation," Journal of Pediatric Gastroenterology and Nutrition 16:321-327 (1993).
Onyekaba, C.O. et al., "Persistent infection of mice by lactate dehydrogenase-elevating virus: effects of immunosuppression on virus replication and antiviral immune responses," Virus Research 14:297-316 (1989).
Rosnewirth, B. et al., "Inhibition of Human Immunodeficiency Virus Type 1 Replication by SDZ NIM 811, a Nonimmunosuppressive Cyclosporine Analog," Antimicrobial Agents and Chemotherapy 38(8):1763-1772 (Aug. 1994).
Suresh, M. et al., "Hemorrhagic enteritis virus induced changes in the lymphocyte subpopulations in turkeys and the effect of experimental immunodeficiency on viral pathogenesis," Veterinary Immunology and Immunopathology 45:139-150 (1995).
Wang et al. "In Vitro Effect of FK506 on Lymphocyte Activation and Viral Replication in Chronic Hepatitis 13 Carriers", Hepatology, vol. 16 (4 part 2), Abst. 292A, 1992.
Shiraki et al. "Effect of FK506 on Replication of Human Cytomegalovirus In Vitro," J. Antibiot., vol. 44, No. 5, pp. 550-552, 1991.

Affiliated with

Also associated with

Rating

Antiviral compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antiviral compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antiviral compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-325630