Antiviral compositions and methods of use

Details Antiviral compositions and methods of use Antiviral compositions and methods of use

2006-07-04

2006-07-04

Tsang, Cecilia J. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S885000, C549S469000

Reexamination Certificate

active

07071227

ABSTRACT:
Purified antiviral compounds, pharmaceutical formulations containing the compounds, and methods of use of the compounds are provided. The compositions of the invention are isolated antiviral components from plant extracts derived from, for example,Salvia miltiorrhiza, that find use in the treatment of viral infections, such as by inhibiting the activity of viral integrase. Methods for isolation and purification of the antiviral compounds are additionally provided.

REFERENCES:
Lim et al , Phytoherapy Research 11(7) , “Inhibitory effects of Cordia spinescens extracts and their constituents on reverse transcriptase and protease from human immunodeficency”, pp. 490-495 (1997).
Lim et al, Chem. Abs. vol. 128 No. 43466 (1997).
Ebersold et al “Human and nurine monoclonal antibody . . . ” CA 117:169322 (1992).
Scarlatti et al “In vivo evolution . . . ” CA.
Cho et al “Identification of determinants . . . ” CA 128:216242 (19998).
Howard et al “Inhibition of in vitro and in vivo . . . ” CA 129:49262 (1998).
Richman “Antiretroviral drug . . . ” Activiral chemotheraphy 4 ed. Mills, Plenum Press, p. 383-395 (1996).
Yarchoan et al “Challenges in the therapy of HIV infection” Clinical perspective TIPS p. 196-202 (19993).
Flexner et al “Pharmacology of antiretrviral agents” AIDS:biology, daig,Treat. Vincent ed. Lippicott, p. 479-493 (1997).

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