Antiviral compositions

Details Antiviral compositions Antiviral compositions

2011-02-15

2011-02-15

Vu, Jake M. (Department: 1618)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S484000, C424S464000, C424S497000, C424S486000, C514S241000, C514S256000

Reexamination Certificate

active

07887845

ABSTRACT:
The present invention is concerned with pharmaceutical compositions of antiviral compounds which can be administered to a mammal, in particular a human, suffering from a viral infection. These compositions comprise particles obtainable by melt-extruding a mixture comprising one or more antiviral compounds and one or more appropriate water-soluble polymers and subsequently milling said melt-extruded mixture.

REFERENCES:
patent: 2671810 (1954-03-01), Coffman et al.
patent: 2742466 (1956-04-01), Randall et al.
patent: 2748124 (1956-05-01), Burtner et al.
patent: 3478030 (1969-11-01), Short
patent: 3755322 (1973-08-01), Winter et al.
patent: 4096206 (1978-06-01), Boyer
patent: 4450162 (1984-05-01), Kamioka et al.
patent: 4652645 (1987-03-01), Stingelin et al.
patent: 4659363 (1987-04-01), Hubele et al.
patent: 4694009 (1987-09-01), Hubele et al.
patent: 4980371 (1990-12-01), Parker et al.
patent: 5017466 (1991-05-01), Kobayashi et al.
patent: 5064963 (1991-11-01), Dean
patent: 5112835 (1992-05-01), Miyasaka et al.
patent: 5516775 (1996-05-01), Zimmermann et al.
patent: 5574040 (1996-11-01), Bukrinsky et al.
patent: 5691364 (1997-11-01), Buckman et al.
patent: 5716722 (1998-02-01), Hamada et al.
patent: 5837436 (1998-11-01), Mihayashi et al.
patent: 5939099 (1999-08-01), Grabowski et al.
patent: 5962479 (1999-10-01), Chen
patent: 6048866 (2000-04-01), Hutchings et al.
patent: 6093716 (2000-07-01), Davis et al.
patent: 6107301 (2000-08-01), Aldrich et al.
patent: 6197779 (2001-03-01), Andries et al.
patent: 6200977 (2001-03-01), Cushing et al.
patent: 6342503 (2002-01-01), Aldrich et al.
patent: 6528513 (2003-03-01), Cushing et al.
patent: 6835726 (2004-12-01), Cushing et al.
patent: 6878717 (2005-04-01), De Corte et al.
patent: 7037917 (2006-05-01), De Corte et al.
patent: 2038182 (1972-02-01), None
patent: 2611826 (1975-03-01), None
patent: 0135472 (1984-07-01), None
patent: 0145656 (1984-11-01), None
patent: 0270111 (1988-06-01), None
patent: 0541966 (1991-05-01), None
patent: 0588762 (1993-08-01), None
patent: 0371139 (1994-10-01), None
patent: 0872233 (1997-04-01), None
patent: 0795549 (1997-09-01), None
patent: 0834507 (1998-04-01), None
patent: 0945442 (1998-05-01), None
patent: 0872233 (1998-10-01), None
patent: 0945443 (1999-09-01), None
patent: 0945447 (1999-09-01), None
patent: 1245567 (2002-02-01), None
patent: 2099730 (1973-08-01), None
patent: 2398740 (1979-03-01), None
patent: 2400535 (1979-04-01), None
patent: 1010998 (1965-11-01), None
patent: 1477349 (1977-06-01), None
patent: 1483271 (1977-08-01), None
patent: 211774 (1991-11-01), None
patent: 206328 (1992-05-01), None
patent: 2-52360 (1990-02-01), None
patent: 2-300264 (1990-12-01), None
patent: 2-308248 (1990-12-01), None
patent: 4159381 (1992-06-01), None
patent: 080199163 (1996-08-01), None
patent: 9-68784 (1997-03-01), None
patent: 09080676 (1997-03-01), None
patent: 090101590 (1997-04-01), None
patent: 11-116555 (1999-04-01), None
patent: 2000111191 (2000-04-01), None
patent: 143808 (1962-01-01), None
patent: WO 90/12790 (1990-11-01), None
patent: WO 91/18887 (1991-12-01), None
patent: WO 92/00952 (1992-01-01), None
patent: WO 94/00513 (1994-01-01), None
patent: WO 94/02470 (1994-02-01), None
patent: WO 94/18963 (1994-09-01), None
patent: WO 95/10506 (1995-04-01), None
patent: WO 95/15952 (1995-06-01), None
patent: WO 96/00068 (1996-01-01), None
patent: WO 96/01110 (1996-01-01), None
patent: WO 97/10887 (1997-03-01), None
patent: WO 97/19065 (1997-05-01), None
patent: WO 98/41512 (1998-09-01), None
patent: WO 00/27825 (2000-05-01), None
Merriam-Webster's Collegiate Dictionary (Merriam-Webster Incorporated: Springfield, Massachusetts, 1993, pp. 311).
Acharya, J., et al. “Studies in s-Triaziny Compounds as Potential Medicinal Agents: Part I”, J. Indian Chemistry Soc., vol. LII, (1975) pp. 1190-1192.
Acharya, J., et al. “Studies on s-Triazinyl Compounds as Potential Medicinal Agents. Part II”., J. Indian Chemistry Soc., vol. LIII, (1976) pp. 193-195.
Aoyagi T., et al. “Synthesis of 2-Amino-2-deoxo-5-Deazaflavins and Related Compounds”, J. Heterocyclic Chemicals, vol. 28(6) (1991) pp. 1537-1539.
Arnold, E., 21th European Crystallographic Meeting, Durban, South Africa, Aug. 27, 2003.
Arutyunyan, E.A., et al., “Reaction of Uracils with Phosphoric Acid Amides”, Institute Org. Khim. Im. Zelinskogo, IZV. Akad. Nauk SSSR, ser Khim, 1970, 4, 904-909 English Abstract Provided.
Ashley, J., et al. “The Search for Chemotherapeutic Amidines. Part XIV. Amidinoanilino-1,3-5-Triazines and Related Compounds”, Journal of Chemical Society, (1960) pp. 4525-4532.
Campbell, J. R., et al. “Unsymmeetrically Substituted Melamines”, Contribution from the Organic Chemicals Division, Research Department, Monbanto Chemical Co., Aug. 1960.
Chase, B., et al., “The Synthesis of Some Potential Antibacterial Agents”, J. Pharm. Pharmacology (1964) vol. 16(3) pp. 163-173.
Chen, C., et al. “Design and Synthesis of a Series of Non-Peptide High-Affinity Human Corticotrophin-Releasing Factor1Receptor Antagonists”, J. Medical Chemistry, vol. 39 (1996) pp. 4358-4360.
Coats, E., et al. “Correlation Analysis of Pyrimidine Folic Acid Antagonists as Antibacterial”, Eur. J. Med. Chem-Chim. Ther. (1979), vol. 14, Issue 3, pp. 26-27.
Das, K., et al. “Could Multiple Modes of Binding of a Potent NNRTI TMC125-R165335 Explain its Potency Against common Drug-Resistant Mutants?”, 10th Conference on Retroviruses and Opportunistic Infection, Session 72 Poster Presentations (2003).
Deng, et al., “Huozhayaa”, Chem. Abstract 20(3) (1997) p. 13 English Abstract Provided.
Dow Corning Corporation, Bennett's Applications: In the Patents Appeal Tribunal, No. 8 (1974) pp. 235-240.
Folkers, J., et al. “Designing Ordered Molecular Arrays in Two and Three Dimensions”, Supramolecular Architecture, Synthetic Control in Thin films and Solids, Chapter 2, (1992) pp. 10-23.
Furukawa, M., et al. “Syntheses of Compounds Related to Guanidine and Their Inhibitory Action of Growth of HeLa Cells”, Chem. Pharm. Bull, vol. 9 (1961) pp. 914-921.
Frieberg, R., et al. Syntheses von 2,4-Bisalkyl(aryl)amino-6-Cyanamino-1,3,5-Triazinen, Journal f. Parakt. Chemie. Band (1985) pp. 471-478 English Abstract on First Page.
Gazzard, B., et al. “TMC125, a Next-Generation NNRTI1, Demonstrates High Potency After 7 Days Therapy in Treatment-Experienced HIV-1-Infected Individuals with Phenotypic NNRTI”, CROI, Seattle, Feb. 2002 Session 4.
Gazzard, B., et al. “An Open-Label Assessment of TMC 125-a New, Next-Generation NNRTI, for 7 Days in HIV-1 Infected Individuals with NNRTI Resistance”, AIDS (2003) vol. 17, pp. 49-54 Fast Track.
Gazzard, B., et al. “TMC125, a Next Generation NNRT! Demonstrates High Potency After 7 Days Therapy in Treatment-Experienced HIV-1 Infected Individuals with Phenotypic NNRT1-Resistance” Poster No. TuPEB4392, XIV International AIDS Conference Jul. 7-11, 2002, Barcelona, Spain.
Ghoneim, K., et al. “Synthesis and Evaluation of Some 2-, 4-, and 2,4-di-substituted-6-Methylpyrimidine Derivatives for Antimicrobial Activity”, CAPLUS 1988-56043.
Ghoneim, K., et al. “Synthesis and Evaluation of some 2-, 4-, and 2,4-Disubstituted-6-Methylpyrimidine Derivatives for Antimicrobial Activity”, Egypt J. Pharm. Sci, vol. 28, No. 14, (1978) pp. 117-126.
Ghosh, D., et al. “2,4-Bis(arylamino)-5-Methylpyrimidines as Antimicrobial Agents”, J. Med. Chem., 10(5), (1967) pp. 974-975.
Ghosh, D. 2,4-Bis(arylamino)pyrimidines as Antimicrobial Agents J. Med. Chem. 9(3) (1966) pp. 423-424.
Ghosh, D. “2,4-Bis Arylamino)-6-Methyl Pyrimidines as Antimicrobial Agent”, J. Indian Chem. Soc., vol. 63 (1981) pp. 512-513.
Ghosh, D., “2,4-Bis(p-Chloroanilino)-Pyrimidine, An Uncoupler of Oxidative Phosphorylation”, FEBS Letters, vol. 4, No. 3 (1969) pp. 157-159.
Ghosh, D., “2,4-Bis(arylamino)-6-methylpyrimidines as Antimicrobial

Affiliated with

Also associated with

Rating

Antiviral compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antiviral compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antiviral compositions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2646331