Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-03-14
1990-05-22
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3140
Patent
active
049278436
ABSTRACT:
The invention relates to novel pharmaceutical compositions which are effective against a wide spectrum of viruses belonging to the Retroviridae family. The active ingredient of the compositions is a thiosemicarbazone compound as herein defined. The compounds are similar to the well-known compound M-IBT (methyl isatin-.beta.-thiosemicarbazone) which has been widely used against smallpox. Contrary to the compounds used according to the present invention, one of which is novel by itself, M-IBT is not effective against viruses of the Retroviridae against which the novel compositions are active.
REFERENCES:
patent: 3253991 (1966-05-01), Bauer et al.
Chemical Abstracts 92:174238y (1980).
Chemical Abstracts 102:89706e(1985) Abstraction.
Chemical Abstracts 103: 153403d (1985) Abstraction.
Activiral Res. 1985, Ronen et al. 5(4) 249-54.
Bauer, D. (ed), "Chemotherapy of Virus Diseases", vol. 1 (1972), published by Pergamon Press Oxford in International Encyclopedia of Pharmacology and Therapeutics pp. 35 & 36.
Zinsser Microbiology, 17th Ed., published by Appleton-Century-Crofts, New York, (1980), pp. only 3 pages of table 62-4.
Goldberg Jerome D.
Ramot Univ. Authority for Applied Res. & Devp. Ltd.
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