Antiviral compositions

Details Antiviral compositions Antiviral compositions

1987-08-07

1990-02-06

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

514738, A61K 3105, A61K 31045

Patent

active

048988910

ABSTRACT:
The invention relates to antiviral compositions of matter containing as active ingredient hypericin or pseudohypericin. The novel compositions are of special use in the treatment of, and alleviation of symptoms of various diseases caused by viruses such as vesicular stomatitis, influenza, herpes simplex, HSV-1 and HSV-2. The mode of activity seems to be by inhibition of RNA synthesis and interfering with virus replication. The pharmaceutical compositions can be applied by a variety of routes. Topical applications have proved to be effective against a variety of viral afflictions.

REFERENCES:
Chemical Abstracts, 66:88613y, (1967).
Chemical Abstracts, 75:91286k, (1971).
Harry, Cosmetic Materials, vol. 2, 1963, Chemical Publishing Co., Inc., N.Y., N.Y., pp. 352-353.
Brockmann et al., "Isolation and Constitution of Pseudohypericin", Chemical Abstracts, 81:528, (1974).
Brockmann et al., "Constitution of Pseudohypericin", Chemical Abstracts, 139833k:(1), 37-40, (1975).
Muldner, "Antidepressive Effect of a Hypericum Extract Standardized to the Active Hypericine Comples; Biochemistry and Clinical Studies", Embase Abstract No. 84174869, (1984).
Okpanyi et al., "Experimental Animal Studies of the Psychotropic Activity of a Hypericum Extract", Chemical Abstracts, 106:113450x, (1987).
Song et al., "Proton Release from Stentor Photoreceptors in the Excited States", Biophys. J., 35:551-555, (1981).
Neumann, H., "Hautpflege met Neuen Wirkstoffen", Seifen-Ole-Fette-Wachse, 92 (21), 759-61, (1966).
Chemical Abstracts, 52:16317f, (1958).
Chemical Abstracts, 52:10039h, (1958).
Derbentseva, N. A. et al., "Effect of Tannins from Hypericum perforatum on Influenza Viruses", Chemical Abstracts, 78:67532d, 1973.
Mishenkova, E. L. et al., "Antiviral Properties of St. John's Wort and Preparations Produced from it", Chemical Abstracts 85:187161y, 1976.
Merck Index, Eighth edition, Stecher, O. G., editor, 1968, p. 558, "Hypericin".
Daniel, K., "Further Communications on the Photodynamic Substance, Hypericin", Chemical Abstracts, 46:9721e, 1952.

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