Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from allium
Reexamination Certificate
2000-08-03
2002-01-22
Weber, Jon P. (Department: 1651)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Containing or obtained from allium
C514S707000
Reexamination Certificate
active
06340483
ABSTRACT:
FIELD OF THE INVENTION
The invention relates to a novel plant extract and therapeutic use thereof. More particularly, the present invention relates to the use of a novel plant extract for treating AIDS and other viral infections.
BACKGROUND OF THE INVENTION
The use of plant derived compositions as therapeutic agents has been known for thousands of years. In particular, the Chinese are known for their herbal therapies. Recently, there has been a resurgence in the use of natural and plant-derived materials that supposedly possess therapeutic activity and promote general well being. For example, many persons now take St. John's Wort, purportedly to alleviate depression and promote general well being. Also, Ginkgo Biloba, purportedly to enhance memory, is widely used now. Further, SAMe, a yeast-derived material which purportedly is useful for treatment of osteoarthritis and alleviation of depression, is in wide use.
In particular, the use of materials derived from a plant of the Allium family, especially
Allivum sativum
(“garlic”) has been reported in the literature. For example, several patents by Tatarintsev et al report the use of ajoene compound, derived from the garlic plant, for treating a variety of ailments including AIDS, inflammation, arthritis, transplant, infection, autoimmune diseases such as lupus, tuberculosis, tumors, and other relates diseases. (See U.S. Pat. Nos. 5,856,363; 5,863,955; 5,948,821; and 5,932,621.)
Also, Hibi, U.S. Pat. No. 5,612,077, describes an ajoene-containing extract from garlic for use in treating arteriosclerosis, tuberculosis, and bronchitis. Further, Tsuei, U.S. Pat. No. 4,795,636; Seebeck, U.S. Pat. No. 2,642,374; and Spinka et al, U.S. Pat. No. 2,618,561, describe garlic extracts as medicinal agents.
Further, the isolation of compounds from plant materials, including Allium that inhibit apoptosis has been reported. See especially, U.S. Pat. Nos. 5,567,425; 5,759,548; 4,986,985; 5,620,885; 5,624,672; 5,635,186; and 5,635,187, by Bathurst et al, all of which are incorporated by reference in their entirety herein.
The foregoing is only exemplary of plant-derived materials reported to possess medicinal properties. However, notwithstanding the large number of plant-derived materials reported to possess therapeutic properties, there still exists a need for novel plant extracts and therapeutic use thereof as such therapies may be safer and more cost effective than traditional medical treatments.
OBJECTS OF THE INVENTION
It is an object of the invention to provide a novel plant extract derived from a plant species of the family Alliaceae (also known as Lilliaceae or Amaryllidaceae), preferably of the genus Allium, with the proviso that said Allium is not garlic (
Allium sativum
), having medicinal properties.
It is a more specific object of the invention to provide novel plant extracts derived from an Allium species selected from the group consisting of
Allium cepa, Allium ampeloprasum
(“leek”),
Allium fistulosa
(Japanese bunching onion, scallion or Welsh onion), or
Allium schoenoprasum
(“chives”) having medicinal properties.
It is an even more specific object of the invention to provide a novel plant extract derived from
Allium cepa
, preferably
Allium cepa
var.
Ancasti
or Southporth white glove (SWG) having medicinal properties.
It is a more specific object of the invention to provide a novel method of treating or preventing a retroviral infection such as HIV-1 or HIV-2 or AIDS by administering a plant extract derived from an Allium species other than
Allivum sativum
, preferably
Allium cepa, Allium fistulosa, Allium ampeloprasum
or
Allium schoenoprasum
, and most preferably
Allium cepa.
It is a more specific object of the invention to treat wasting syndrome, especially associated with AIDS, and/or to lengthen the latency period of HIV infection, and/or to delay the latent phase of AIDS, and/or to ameliorate or eliminate the clinical symptoms associated with AIDS such as intestinal problems, diarrhea, neurological impairment and paresthesia by administering a medicinal extract derived from an Allium species other than
Allivum sativum
, preferably
Allium cepa, Allium fistulosa, Allium ampeloprasum
or
Allium schoenoprasum
, and more preferably
Allium cepa.
It is another specific object of the invention to inhibit or treat microbial infection, e.g., fungal, yeast or Candidiasis infection in a subject in need of such inhibition or treatment, comprising administering a medicinal extract derived from an Allium species other than
A. sativum
, preferably
Allium cepa, Allium fistulosa, Allium ampeloprasum
or
Allium schoenoprasum
and most preferably
Allium cepa.
It is another specific object of the invention to modulate the immune system of a subject in need of such treatment, by administering a medicinal extract derived from an Allium species other than
Allivum sativum
, preferably
Allium cepa.
It is an object of the invention to provide a novel method of treating or preventing viral infection by administering a medicinal extract derived from an Allium species other than
Allivum sativum.
It is a more specific object of the invention to provide a novel method of treating or preventing viral infection by administering a medicinal extract derived from an Allium species selected from the group consisting of
Allium cepa, Allium ampeloprasum, Allium fistulosa
, and
Allium schoenoprasum.
It is an even more specific object of the invention to provide a novel method of treating or preventing viral infection by administering a medicinal extract derived from
Allium cepa
, preferably the variety Ancasti or Southporth white glove.
It is another object of the invention to immunostimulate the immune system of a subject in need of such treatment by administering a medicinal extract derived from an Allium species other than
sativum
, preferably
Allium cepa, Allium fistulosa, Allium schoenoprasum
or
Allium ampeloprasum
and more preferably
Allium cepa.
It is another object of the invention to enhance T cell function and/or T cell proliferation, and/or T-cell differentiation, by administering a medicinal extract derived from an Allium species other than
Allivum sativum
, preferably
Allium cepa, Allium fistulosa, Allium schoenoprasum
or
Allium ampeloprasum
, most preferably
Allium cepa.
It is another specific object of the invention to identify and isolate the active constituent or constituents comprised in the Allium extract disclosed herein having antimicrobial, antifungal, antiviral, immunomodulatory, T cell function or proliferation inducing, and/or immunostimulatory activity.
It is another specific object of the invention to promote weight gain in a subject in need of such treatment by administering an effective amount of a medicinal extract derived from an Allium selected from
Allium cepa, Allium fistulosa, Allium schoenoprasum
or
Allium ampeloprasum
, most preferably
Allium cepa.
It is another object of the invention to treat animal microbial infections, especially viral infections such as distemper or parvovirus or bacterial infections such as psittacosis, by administering a medicinal extract derived from
Allium cepa.
It is another object of the invention to provide a method for producing a medicinal extract from Allium species selected from
Allium cepa, Allium fistulosa, Allium schoenoprasum
or
Allium ampeloprasum.
It is another object of the invention to provide a novel medicinal extract derived from
Allium cepa, Allium fistulosa, Allium schoenoprasum
, or
Allium ampeloprasum
, preferably orally administrable.
It is another specific object of the invention to provide a novel regimen for treating AIDS that includes a dietary regimen, no administration of conventional AIDS medications such as protease inhibitors, anti-retrovirals, or other chemotherapeutics causing multiple side effects (other than antibiotics) and administration of a medicament derived from a plant of the genus Allium, preferably
Allium cepa.
DETAILED DESCRIPTION OF THE INVENTION
The present invention is based on the discover
Goldman Simon Raul
Goldman Walter Franklin
Goren Adolfo
Trainin Zila
Burns Doane Swecker & Mathis L.L.P.
Diepon, S.A.
Guttman Harry J.
Weber Jon P.
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