Antiviral composition and method

Details Antiviral composition and method Antiviral composition and method

1992-02-24

1993-05-25

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Food or edible as carrier for pharmaceutical

424430, 424436, 424609, 424663, 424686, 514855, 514934, 514966, 514967, A61K 968

Patent

active

052138038

ABSTRACT:
A method utilizing compositions for topical application which are adapted for the prevention and treatment of viral infections such as Herpes, AIDS and other envelope virus infections are disclosed. The compositions of the present invention produce a synergistic anti-viral effect when used in combination. The formulation contains a humectant such as sorbitol, glycerol, or other comparable compound in the range of 20-80% w/v final concentration, which facilitates structural and/or functional three dimensional disruption or disorientation of the viral envelope. The activation of the destruction of the envelope and subsequent death of the envelope virus is then achieved using combination of inorganic monovalent anions, nonionic detergents and anionic detergents. These monovalent anions can include sodium bicarbonate, sodium thiocyanate, sodium fluoride and sodium chloride at about 0.5 to 5% w/v final concentration; nonionic detergents such as Tween 20 at concentrations of about 0.1% to 3% v/v, ethanol up to about 15% v/v, and other antimicrobial agents such as chlorhexidine or comparable basic substances at concentrations from about 0.01 to 0.2% v/v. The formulation may also include anionic surfactants, flavor and water added to 100%.

REFERENCES:
patent: 3956480 (1976-05-01), Dichter et al.
patent: 4661493 (1987-04-01), Gibbs
patent: 4759925 (1988-07-01), Gaffar et al.
patent: 4861582 (1989-08-01), Pollock et al.
patent: 4863900 (1989-09-01), Pollock et al.
patent: 4915936 (1990-04-01), Patterson et al.
patent: 4950479 (1990-08-01), Hill et al.
patent: 4980150 (1990-12-01), Keith
patent: 4981875 (1991-01-01), Leusner et al.
Yash et al., American Clinical Laboratory, 23-32 (Oct. 1990).
Park et al., Oral Surg. Oral Med. and Oral Path., 67, 149-153 (1989).
Zimmerman et al, J. Med. Virol., 15, 215-222 (1985).
McCaughtry et al, J. Med. Virol., 10, 283-290 (1982).
DeClerq et al, Proc. Nat. Acad. Sci. USA, 76, 2947-2951 (1979).
Docherty et al., Proc. Soc. Exp. Biol. Med., 136, 328-333 (1971).
Hoxie, et al., Science, 234, 1123-1127 (1986).

Affiliated with

Also associated with

Rating

Antiviral composition and method does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antiviral composition and method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antiviral composition and method will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-895980