Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1995-04-17
1997-02-04
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
A61K 3122
Patent
active
055998399
ABSTRACT:
The present invention relates to an antiviral composition and to methods of treating patients with viral infections. The antiviral composition of the present invention comprises prostratin, a phorbol ester derivative, and a pharmaceutically acceptable carrier. The present composition while having antiviral activity does not have substantial tumor promoting activity and does not have other substantial adverse toxicological properties that would preclude its use in antiviral therapy.
REFERENCES:
patent: 4902716 (1990-02-01), Higa et al.
Chu et al., J. Med Chem. 1989, 32 612-617.
Cashmore et al., Tetrahedron Letters No. 20, pp. 1737-1738 (1976).
Boyd, in AIDS Etiology, Diagnosis, Treatment, and Prevention, 2nd Edition, J. B. Lippincott Co, N.Y., pp. 305-319, 1987.
International Search Report.
"The structure of prostratin: A toxic tetracyclic Di Terpene ester from pimelea prostrata", Tetrahedron letters, 20:1737-1738 (1976) entire reference.
Beutler John A.
Blumberg Peter M.
Boyd Michael R.
Cardellina, II John H.
Cox Paul A.
Brigham Young University
Goldberg Jerome D.
The United States of America as represented by the Department of
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