Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Patent
1991-08-20
1992-08-11
Lacey, David L.
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
530351, 530331, 424450, 424 92, 514 8, A61K 3766
Patent
active
051377209
ABSTRACT:
Described is a synergistic pharmaceutical combination preparation comprising as component A a hybrid .alpha.-interferon the structure of which is derived from human interferon-.alpha.-D and -.alpha.-B gene fragments and as component B a muramylpeptide. The preparation can be used for treating viral diseases or reducing the formation of metastases of certain tumors.
REFERENCES:
patent: 4774085 (1988-09-01), Fidler
Goeddel et al., Nature 290: 20-26 (1981).
Utsugi et al., Journal of Immunology vol. 136 No. 3 (1986) pp. 1117-1122.
Saiki et al., Journal of Immunology, vol. 135, No. 1, pp. 684-688 (1985).
Fidler et al., Journal of Immunology, vol. 135, No. 6, pp. 4289-4296 (1985).
Sone et al., Int. J. Cancer, vol. 38, pp. 495-500 (1986).
Gangemi J. David
Hochkeppel Heinz-Kurt
Ciba-Geigy Corporation
Fishman Irving M.
Guest Shelly J.
Kaiser Karen G.
Lacey David L.
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