Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Silicon containing doai
Patent
1987-03-05
1990-11-06
Rivers, Diana G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Silicon containing doai
514261, 514262, 514263, 514258, 514303, 544254, 544265, 544267, 544276, 544277, 544279, 546118, A61K 3152, C07D47316, C07D47318
Patent
active
049686747
ABSTRACT:
A compound of the formula: ##STR1## wherein R is a hydroxyl group which may be protected and Y is a purine base which may be protected, and the saltts thereof, which are useful as an antiviral agent.
REFERENCES:
patent: 3917837 (1975-11-01), Lin et al.
patent: 4543255 (1985-09-01), Shealy, et al.
patent: 4605659 (1986-08-01), Verheyden et al.
patent: 4782062 (1988-11-01), Tolman et al.
patent: 4916224 (1990-04-01), Vince et al.
Symposium Series 16 1985, Nucleic Acids Research, pp. 141-142, Miyashita et al.
Santi et al., "Phenylalanyl Transfer Ribonucleic Acid Synthetase from Escherichia Coli. Analysis of the Adenosine Triphosphate Binding Site", Biochemistry, vol. 10, No. 25, pp. 4821-4824, 1971.
Coward et al., "Analogs of S-Adenosylhomocysteins as Potential Inhibitors of Biological Transmethylation. Specificity of the S-Adenosylhomocysteine Binding Site", J. Medicinal Chemistry, vol. 16, No. 5, pp. 460-463, May 1973.
Chemical and Pharmaceutical Bulletin, vol. 24, 2624-2628 (1976), Marumoto et al.
Journal of Medical Chemistry, 1986, vol. 29, No. 9, 1561-1569, DeClereq.
Proc. Natl. Acad. Sci. U.S.A. 83 (1986), pp. 1911-1915, Mitsuya et al.
Marquez et al., Biochemical Pharmacology, vol, 36, No. 17, pp. 2719-2722 (1987).
York, J. Org. Chem., vol. 46, No. 10, pp. 2171-2173 (1981).
Drayer, et al., Clinical Pharmacology & Therapeutics, vol. 40, No. 3, pp. 125-133 (08/86).
Kato et al., Yakabutu Doutai(pharmokinetics), vol. 2, No. 2, pp. 171-182 (1987).
Schaeffer et al., J. Pharm. Sci., vol. 53, No. 12, pp. 1510-1515 (12/64).
Marquez et al., "Carbocyclic Nucleosides", Medicinal Research Reviews, vol. 6, No. 1, pp. 1-8, 11-16 and 37-40 (1986).
Montgomery et al., J. Am. Chem. Soc., vol. 80, pp. 409-411 (1958).
Shealy et al., Chemical Abstracts, vol. 71:81310s (1969.
Shealy et al., Chemical Abstracts, vol. 101:192384b (1984).
Miyashita et al. Chemical Abstracts, vol. 106:84996x (1987), abstract of Japan 60,215,685, 10/29/85.
Hamana Takumi
Marumoto Ryuji
Taniyama Yoshio
Yamamoto Naoki
Rivers Diana G.
Takeda Chemical Industries Ltd.
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