Antiviral antibiotic BU-4344V

Details Antiviral antibiotic BU-4344V Antiviral antibiotic BU-4344V

1990-11-21

1992-08-18

Lilling, Herbert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

435 713, 435825, 530321, C12P 2104, C12R 103, C07K 754

Patent

active

051401010

ABSTRACT:
There is provided a new antiviral antibiotic designated herein as BU-4344V which is produced by fermentation of a BU-4344V-producing strain of a new microorganism, Actinomadura parvosata subsp. kistnae ATCC No. 55076. Antibiotic BU-4344V is recovered and purified from the fermentation broth by use of extraction, chromatography, and crystallization techniques. BU-4344V has been found to have some antibacterial activity and inhibits the growth of viruses, including influenza virus type A.

REFERENCES:
patent: 4328211 (1982-05-01), Sugawara et al.
patent: 4399067 (1983-08-01), Debono
patent: 4882419 (1989-11-01), Malabarba et al.
patent: 4946941 (1990-08-01), Kondo et al.

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