Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1990-07-06
1992-03-24
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
514 25, 424114, 424115, 424116, 424117, 424 858, A61K 3710, A61K 31395, C12P 1718
Patent
active
050987089
ABSTRACT:
Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A.sub.1, A.sub.2, A.sub.3, D.sub.1, D.sub.2 and D.sub.3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.
REFERENCES:
patent: 4675187 (1987-06-01), Konishi et al.
patent: 4916065 (1990-04-01), Ohkuma et al.
patent: 4960755 (1990-10-01), Nishio et al.
Sandstrom et al., Anti-Viral Therapy in AIDS, AIDS Press Limited, pp. 373-390, 1987.
Mitsuya et al., Retroviruses in Human Lymphoma/Leukemia, "Protection of T Cells Against Infectivity and Cytopathic Effect of HTLV-III in Vitro", pp. 277-288, 1985.
Konishi Masataka
Miyaki Takeo
Oki Toshikazu
Tenmyo Osamu
Tsunakawa Mitsuaki
Bristol--Myers Squibb Company
Griffin Ronald W.
Levy Ron K.
Morse David M.
Yang Mollie M.
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