Antiviral agents

Details Antiviral agents Antiviral agents

2006-07-18

2006-07-18

Jiang, S. Anna (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S247000, C514S362000, C514S363000, C514S364000, C514S365000, C514S373000, C514S374000, C514S379000, C514S277000, C514S255030, C514S256000, C514S242000, C514S430000, C514S449000, C544S224000, C544S336000, C544S242000, C544S180000, C544S182000, C546S001000, C546S348000, C548S136000, C548S143000, C548S128000, C548S131000, C548S146000, C548S215000, C548S206000, C548S240000, C549S029000, C549S506000

Reexamination Certificate

active

07078403

ABSTRACT:
Disclosed herein are compounds of formula II:wherein Alk, Z, X1, X2, R1, —R10and R11are defined herein, and their salts and pharmaceutically acceptable derivatives thereof, as well as other compounds of the general formula Het-A-Alk-W-Ar-C(X2)═NO-X2where Het, A, W and Ar are also defined herein. These compounds are useful in treating picornavirus infections in mammals. Novel intermediates of these compounds, as well as pharmaceutical compositions and methods of use, are also disclosed herein.

REFERENCES:
patent: 3997565 (1976-12-01), Kauer
patent: 4268678 (1981-05-01), Diana et al.
patent: 4451476 (1984-05-01), Diana
patent: 4472416 (1984-09-01), Stetter et al.
patent: 4843087 (1989-06-01), Diana
patent: 4857539 (1989-08-01), Diana et al.
patent: 4861791 (1989-08-01), Diana et al.
patent: 4939267 (1990-07-01), Diana
patent: 4942241 (1990-07-01), Diana et al.
patent: 4945164 (1990-07-01), Diana
patent: 4956351 (1990-09-01), Mesens et al.
patent: 4992433 (1991-02-01), Stokbroekx et al.
patent: 5001125 (1991-03-01), Stokbroekx et al.
patent: 5002960 (1991-03-01), Diana
patent: 5051437 (1991-09-01), Diana
patent: 5070090 (1991-12-01), Stokbroekx et al.
patent: 5100893 (1992-03-01), Stokbroekx et al.
patent: 5106973 (1992-04-01), Stokbroekx et al.
patent: 5110821 (1992-05-01), Diana
patent: 5112825 (1992-05-01), Stokbroekx et al.
patent: 5175178 (1992-12-01), Diana et al.
patent: 5196535 (1993-03-01), Stokbroekx et al.
patent: 5231184 (1993-07-01), Stokbroekx et al.
patent: 5242924 (1993-09-01), Diana
patent: 5349068 (1994-09-01), Diana et al.
patent: 5364865 (1994-11-01), Diana
patent: 5453433 (1995-09-01), Aldous et al.
patent: 5464848 (1995-11-01), Diana et al.
patent: 5514679 (1996-05-01), Aldous et al.
patent: 5514692 (1996-05-01), Aldous et al.
patent: 5523312 (1996-06-01), Aldous et al.
patent: 5552420 (1996-09-01), Aldous et al.
patent: 5567717 (1996-10-01), Aldous et al.
patent: 5567719 (1996-10-01), Aldous et al.
patent: 5618821 (1997-04-01), Aldous et al.
patent: 5643929 (1997-07-01), Diana et al.
patent: 5650419 (1997-07-01), Aldous et al.
patent: 5665763 (1997-09-01), Aldous et al.
patent: 5721261 (1998-02-01), Aldous et al.
patent: 5750527 (1998-05-01), Aldous et al.
patent: 5763461 (1998-06-01), Aldous et al.
patent: 5821257 (1998-10-01), Aldous et al.
patent: 5846986 (1998-12-01), Aldous et al.
patent: 6048880 (2000-04-01), Kawai et al.
patent: 6696470 (2004-02-01), Kawai et al.
patent: 2004/0054173 (2004-03-01), Kimura et al.
patent: 0 248 253 (1987-12-01), None
patent: 0290906 (1988-11-01), None
patent: 0 398 425 (1994-03-01), None
patent: 1070711 (2001-01-01), None
patent: 5-320117 (1993-12-01), None
patent: 8-81314 (1996-03-01), None
patent: WO 90/01874 (1990-03-01), None
patent: WO 98/17631 (1998-04-01), None
patent: WO 01/19822 (2001-03-01), None
Andries, K., “Discovery of pirodavir, a broad-spectrum inhibitor of rhinoviruses,” inThe search for antiviral drugs. Adams, J. and Merluzzi, VJ., (eds) Berkhauser, Boston USA, 1993, pp. 179-209.
Arruda, E and Hayden, FG., “Clinical studies of antiviral agents for picornaviral infections,” inAntiviral Chemotherapy, Jeffries, DJ. and DeClercq, E. (ed). John Wiley & Sons Ltd., Sussex, England, 1995, pp. 321-355.
Rogers, JM et al., “Pleconaril. A broad spectrum antipicornavirus agent,” inAntiviral Chemotherapy 5, Mills et al. (ed), Kluwer Academic/Plenum Publishers, NY, USA, 1999, pp. 69-76.
Rotbart, HA et al., “Treatment of human enterovirus infections,”Antiviral Research38: 1-14, 1998.
Schiff, GM and Sherwood, JR, “Clinical activity of Pleconaril in an experimentally induced Coxsackievirus A21 respiratory infection,”The Journal of Infectious Diseases, 181:20-26, Jan. 2000.
Adams and Merluzzi (eds.),The Search for Antiviral Drugs: Case Histories from Concept to Clinic, Birkhouse, Boston, 1993, Chapter 8, pp. 179-209.
Diana et al., “Antipicornavirus drugs: current status,”Antiviral Chemistry and Chemotherapy 8(5):401-408, 1997.
Hayden et al., “Intranasal pirodavir (R77,975) treatment of rhinovirus colds,”Antimicrobial Agents and Chemotherapy 39(2):290-294, Feb. 1995.
Hayden et al., “Safety and efficacy of intranasal pirodavir (R77975) in experimental rhinovirus infection,”Antimicrobial Agents and Chemotherapy 36(4):727-732, Apr. 1992.
Patani et al., “Bioisosterism: A Rational Approach in Drug Design,”Chemical Reviews 96(8):3147-3176, Dec. 1996.
Sushil K. Starling, et al., “Anti-inflammatory & Anti-arrhythmic Activities of I-(Alkanoylphenoxy/Thiophenoxy)-3-(N4-phenylpiperazinyl)propanes,”Indian Journal of Chemistry 15B:715-719, Aug. 1977.
Joseph T. Strupczewski et al., “3-[[Aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles as D2/5-HT2Antagonists with Potential Atypical Antipsychotic Activity: Antipsychotic Profile of Iloperidone (HP 873)1,”J. Med Chem. 38:1119-1131, 1995. (Mar. 1, 1995).
Michael S. Malamas et al., “Azole Phenoxy Hydroxyureas as Selective and Orally Active Inhibitors of 5-Lipoxygenase,”J. Med. Chem. 39:237-425, 1995.(Dec. 15, 1995).

Affiliated with

Also associated with

Rating

Antiviral agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antiviral agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antiviral agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3547707