Antiviral agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Sulfur – selenium or tellurium compound

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514718, A61K 3110

Patent

active

058744789

ABSTRACT:
This invention relates to compounds, compositions, uses and methods for inhibiting viral and retroviral replication and for treating viral and retroviral infections via the administration of various compounds, including antioxidants, preferably compounds corresponding to the formula ##STR1## wherein n=1, 2, 3, or 4; m=0 or 1; X is O, S or CH.sub.2 ; R.sub.1 is hydrogen or tertiary butyl or lower alkyl of from one to six carbon atoms, inclusive; R.sub.2 is tertiary butyl or lower alkyl of from one to six carbon atoms, inclusive; and R.sub.3 is hydrogen or alkyl or aryl or mixed alkyl/aryl, containing a total of 5-25 carbon atoms.

REFERENCES:
patent: 3129262 (1964-04-01), Laufer et al.
patent: 3574853 (1971-04-01), Barnhart
patent: 3576883 (1971-04-01), Neuworth
patent: 3692907 (1972-09-01), Fleming et al.
patent: 3862332 (1975-01-01), Barnhart et al.
patent: 3956359 (1976-05-01), Neuworth
patent: 4084006 (1978-04-01), Leach
patent: 4115590 (1978-09-01), Lerner
patent: 4192896 (1980-03-01), Leach et al.
patent: 4350707 (1982-09-01), Keith et al.
patent: 4560799 (1985-12-01), Spivack et al.
patent: 4719237 (1988-01-01), McCaughan
patent: 4835190 (1989-05-01), Mueller et al.
patent: 4847305 (1989-07-01), Mueller et al.
patent: 4992475 (1991-02-01), Marcel
Carew CA; 108:16125d 1988.
Brugh, M., Chemical Regulation of Immunity in Veterinary Med., A.R. Liss, 1984, pp. 229-234.
Brugh, M., Science 197: 1291 (1977).
Winston, et al., Am. J. Vet. Res. 41: 391 (1980).
Reimund, E., Medical (HIV) Hypotheses 23: 39 (1987).
Cupp, J., et al., Antimicrobial Agents and Chemotherapy 8: 698 (1975).
Pirtle, E.C., et al., Am. J. Vet. Res. 47: 1892 (1986).
Wanda, P., et al., Antimicrobial Agents and Chemotherpy 10: 96 (1976).
Keith, A.D., et al., Proc. Soc. Expltl. Biol. & Med. 170: 237 (1982).
Freeman, D.J., et al., Clin. Pharmacol. Ther. 38: 56 (1985).
Kim, K.S., et al., J. Infec. Dis. 138: 91 (1985).
Lane, et al., "Acquired Immunodeficiency Syndrome and Related Diseases" in Rose, et al., eds., Manual of Clinical Laboratory Immunology, 3d Ed., Am. Soc. Microbiol., pp. 582-586, 1986.
Oda, et al., Science 244: 974-976 (1989).
Aloia et al., PNAS 85: 900 (1988).
Hendler S., "The Oxygen Breakthrough," William Morrow and Company, Inc., New York, 1989.
March, J., Advances Organic Chemistry, 3d ed., J. Wiley and Sons, 1985, pp. 360-362.
March, J., Advanced Organic Chemistry, 3d ed., J. Wiley & Sons, 1985, pp. 793-795.
T. Fujisawa, et al., Synthesis 39 (1973).
Snipes, et al., Chem. Abst. 82: 149903x (1975).
Carew, et al., Chem. Abst. 108: 16125d (1988).
Hendler, S., "The Complete Guide to Anti-Aging Nutrients," Simon and Schuster, New York (1984).
Nara, et al., Aids Res. and Human Retroviruses 3: 283-302 (1987) (Mary Ann Liebert, Publ.).
Nara and Fischinger, Nature 332: 469-470 (1988).
Hammerstedt, R.H., et al., Biology of Reproduction 14: 381-397 (1976).
Carew, T.E., et al., PNAS USA 84: 7725-7729 (1987).
Moldovanyi, et al., Chem. Abst. 109: 197191m (1988).
Hils, et al., Chem. Abst. 106: 2733x (1987).
Weuffen, et al., Chem. Abst. 103: 147169r (1985).
Prakash, et al., Chem. Abst. 96: 117404h (1982).
Kloecking, et al., Chem. Abst. 89: 158049v (1978).
Bydzovska, Chem. Abst. 85: 28509b (1976).
Drake, et al., Chem. Abst. 72: 20544v (1970).
Barnhart et al., Chem. Abst. 73: 64643b (1970).
Kritchevsky, et al., Chem. Abst. 74: 123504c (1971).
Kabara, et al., Chem. Abst. 88: 83965j (1978).
Prous, et al., Chem. Abst. 89: 16371v (1978).
Hoshide, et al., Chem. Abst. 93: 71280x (1980).
Hoshide, et al., Chem. Abst. 93: 94980q (1980).
Hoshide, et al., Chem. Abst. 93: 149970u (1980).
Ramos, et al., Chem. Abst. 95: 150171g (1981).
Mordasini, et al., Chem. Abst. 96: 79712x (1982).
DeMeglio, et al., Chem. Abst. 104: 28675p (1986).
W. Snipes et al., Symp. of the Pharmacolo. Effects of Lipids, The Amer. Oil Chem. Soc., Champaign, IL., 1978, pp. 63-73, "Hydrophobic Alcohols and . . . Antiviral Agents".
D.Y.C. Fung et al., Critical Reviews in Microbiology, vol. 12 No. 2, 1985, pp. 153-183; "Effect of Phenolic Antioxidants on Microbial Growth".
J.E.F. Reynolds, "Martindale The Extra Pharmacopoeia" 29th edition, 1989, The Pharmaceutical Press, London, GB, p. 1203: Probucol.
T. Oda et al., "Oxygen Radicals . . . Conjugated SOD," Science vol. 244, pp. 893-1016; May 26, 1989.

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