Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-09-25
1993-02-02
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548437, A61K 3140, C07D20956
Patent
active
051838265
ABSTRACT:
An antiviral agent produced by Hypoxylon fragiforme and having the structure: ##STR1## is described. The product has high activity as an HIV protease enzyme inhibitor and is useful in the treatment of diseases in which control of HIV protease activity is desirable.
REFERENCES:
patent: 3849437 (1974-11-01), Ousby et al.
Izawa, Y. et al., Tetrahedron 45, 2323 (1989).
Edwards, R. L. et al., J. Chem. Soc. Perkin Trans. I 1989, 57-65.
Berdy, J., CRC Handbook of Antibiotic Compounds vol. II CRC Press, Boca Raton, pp. 427-443.
Cole, R. J. et al., Handbook of Toxic Fungal Metabolites Academic Press, 1981, pp. 289-293.
Beno, M. A. et al., J. Am. Chem. Soc. 99, 4123 (1977).
Bills Gerald F.
Hensens Otto D.
Koupal Lawrence
Lingham Russell B.
Ondeyka John G.
Ambrose Michael G.
Caruso Charles M.
Lee Mary C.
Merck & Co. , Inc.
Polk Manfred
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