Antiviral aerosol compositions and pressurized containers contai

Details Antiviral aerosol compositions and pressurized containers contai Antiviral aerosol compositions and pressurized containers contai

1989-12-19

1991-09-17

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

514738, 424 43, 424 45, 252308, 252311, A01N 3108, A01N 31045, A01N 2502, A61K 914

Patent

active

050495895

ABSTRACT:
The invention relates to antiviral compositions of matter containing as active ingredient hypericin or pseudohypericin. The novel compositions are of special use in the treatment of, and alleviation of symptons of various diseases caused by viruses such as vesicular stomatitis, influenza, herpes simplex, HSV-1 and HSV-2. The mode of activity seems to be by inhibition of RNA synthesis and interfering with virus replication. The pharmaceutical compositions can be applied by a variety of routes. Topical applications have proved to be effective against a variety of viral afflictions.

REFERENCES:
Halm, Gyogyszereszet: Bulletin of Pharmacy, 33, 217-218, 1978.
Mishenkova et al, "Antiviral properties of St. John's Wort and Preparations produced from It" Chem. Abstracts 85: 187161y.
Derbentseva et al, "Effect of Tannins from Hypericum perforatum on influenza Viruses", Chem. Abstracts 78: 67532d.
Brockman et al., "Isolation and Constitution of Pseudohypericin", Cehmical Abstracts, 81:528 (1974).
Brockman et al., "Constitution of Pseudohypericin", Chemical Abstracts, 139833k:(1), 37-40 (1975).
Muldner, "Antidepressive Effect of a Hypericum Extract Standardized to the Active Hypericin Complex; Biochemistry and Clinical Studies", Embase Abstract No. 84174869, (1984).
Okpanyi et al, "Experimental Animal Studies of the psychotropic activity of a Hypericum Extract", Chemical Abstracts, 106:113450x (1987).
Song et al, "Proton Release from Stentor Photoreceptors in the Excited States", Biophys. J., 35:551-555 (1981).
Neumann, H. "Skin food with New active substances", Chemical Abstracts, 66:88613y (1967).
Brockmann, H. et al, "Zur Kenntnis des Hypericins und Pseudo-Hypericins", Chemical Abstracts 52:16317f (1958).
Brockman, H. et al, "Totalsynthese des Hypericins", Chemical Abstracts, 52:10039h, (1958).
Merck index, Eighth edition, Stecher, O. G., editor, 1968, p. 558, "Hypericin".
Daniel, K. "Further Communications on the Photodynamic Substance, Hypericin", Chemical Abstracts, 46:9721e, (1952).
Adamsky, R. et al, "Stability of hypericin in juice, dry extract, and tablets from Hypericum perforatum plants", Chemical Abstracts, 75:91286k (1971).
Harry, R. G., "Cosmetic Materials" vol. 2, 1963, Cheimcal Publishing Co., Inc., N.Y., N.Y. pp. 352-353.
Merck Index, 10th edition, 1983, p. 710, Merck & Co., Inc., Rahway, NJ.
Meruelo, D. et al, "Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: Aromatic polycyclic diones hypericin and pseudohypericin" Proc. Acad. Sci. U.S.A., vol. 85, No. 14, Jul. 1988, pp. 5230-5234.

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