Antiviral 2(1H)-quinazolinone derivatives

Details Antiviral 2(1H)-quinazolinone derivatives Antiviral 2(1H)-quinazolinone derivatives

1974-07-30

1976-07-20

Rush, Raymond V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602564Q, 2602565R, 2602948B, 2602948C, 260295T, 260295K, 260296T, 260296B, 260329S, 260329F, 260562B, 260571, 260576, 424251, C07D23982

Patent

active

039706540

ABSTRACT:
Quinazolinone derivatives of the formula, ##SPC1##
Wherein R is a polyalicyclic hydrocarbon group; R.sup.1 and R.sup.2 are independently a hydrogen atom, a nitro group, a trifluoromethyl group or a methylsulfonyl group; R.sup.3 is a phenyl group, a substituted phenyl group, a pyridyl group or a thienyl group; and n is 0 or an integer of 1 to 3, have potent antiviral activity with low toxicities. These compounds can be prepared using a variety of processes analogous to known methods, for example, by oxidizing a 3,4-dihydro-2(1H)-quinazolinone having a polyalicyclic hydrocarbon group bonded through an alkylene group at the 1 position.

REFERENCES:
patent: 3712892 (1973-01-01), Inaba et al.
patent: 3748342 (1973-07-01), Cooke et al.
patent: 3859237 (1975-01-01), Inaba et al.

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