Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-08-09
2005-08-09
Chin, Christopher L. (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S006120, C435S007230, C435S007400, C435S007930, C435S070210, C435S452000, C435S333000, C436S518000, C436S548000, C436S822000, C530S388210, C530S807000
Reexamination Certificate
active
06927035
ABSTRACT:
A monoclonal antibody which reacts strongly with uracil and thymine but scarcely with N-carbamyl-β-alanine; a hybridoma producing this monoclonal antibody; a method of immunochemically assaying uracil or thymine characterized by using the above-described monoclonal antibody; and diagnostics for DPD deficiency containing the above monoclonal antibody. Because of high sensitivity and specific reaction with uracil and thymine, the above-described monoclonal antibody enables convenient, quick, and selective assaying of uracil and thymine in a sample. The antibody is useful in screening patients with DPD deficient cancer with contraindication to the administration of pyrimidine fluoride-based antitumor agents.
REFERENCES:
patent: 62-299765 (1987-12-01), None
patent: WO 99/20748 (1999-04-01), None
Honda et al., 2002. Development and characterization of a monoclonal antibody with cross-reactivity towards uracil and thymine, and its potential use in screening patients treated with 5-fluorouracil for possible risks. Clinica Chimia Acta 322: 59-66.
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Biomedical Research Group Inc.
Chin Christopher L.
Grun James L.
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
Taiho Pharmaceutical Co., LTD
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