Antiulcer compounds having a substituted alkynyl or quinoxaline

Details Antiulcer compounds having a substituted alkynyl or quinoxaline Antiulcer compounds having a substituted alkynyl or quinoxaline

1995-06-02

1996-12-10

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544354, 544355, 544356, C07D24142, A61K 3133

Patent

active

055832270

ABSTRACT:
This invention relates to a novel compound which is useful as a drug in preventing and/or treating peptic ulcer-related diseases, to a production process thereof and to a pharmaceutical composition containing the same.
Particularly, it provides a compound which has a specified substituted alkynylpyrazine nucleus or a specified substituted alkynylquinoxaline nucleus, represented by the following formula (I) ##STR1## wherein A is represented by the following formula (II) or (III) ##STR2## and R.sup.1 is represented by the following formula (IV), ##STR3## and the salts thereof, a production process thereof and a pharmaceutical composition containing the same.
The inventive compound is useful as a drug in preventing and/or treating peptic ulcer-related diseases.

REFERENCES:
Ames et al., J.C.S. Perkin Trans. I. (7) pp. 1384-1389 (1980).
Ames et al., J. Chem. Research (S), 144-145 (1985).
Akita et al., Chem. Pharm. Bull. 34(4) 1447-1458 (1986).
Iijima et al., Yakagaku Zasshi, 108, No. 6, 586-590 (1988).
Ames et al., Synthesis, No. 5, 364-365 (1981).
Toshihide et al., Patent Abst. of Japan, 5, 45 (C-048) (1981).
Toshihide et al., Patent Abst. of Japan, 5, 41 (C-047) (1981).

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