Antiulcer compounds

Details Antiulcer compounds Antiulcer compounds

1984-10-16

1986-07-01

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530323, 530317, A61K 3743, C07K 508

Patent

active

045980675

ABSTRACT:
A compound having the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein A is N--Ac--Sar, pGlu, or homo-pGlu-; B is an aryl group, a heteroaryl group, a cycloalkyl group, an aralkyl group, a heteroalkyl group, a heteroaralkyl group, a benzoyl group, an alkyl group, an acetyl group, or a substituted aryl group wherein the substituent is halogen, hydroxy, alkoxy, nitro, cyano, or hydroxyalkyl; E is H or an alkyl group; B and E being separate substituents or, together with C.sub.1 and the nitrogen atom to which B is attached, forming a 5,6, or 7-membered ring; m is an integer between 0 and 4; either F is ##STR2## wherein R is an alkoxy group or an aralkoxy group; or F is ##STR3## and is capable of forming a 6-membered ring with the nitrogen atom of A, provided that F can only be ##STR4## forming a ring with A when A is pGlu or homo-pGlu.

REFERENCES:
patent: 4234588 (1980-11-01), Brown
patent: 4328134 (1982-05-01), Schally
patent: 4390701 (1983-06-01), Algieri
patent: 4394508 (1983-07-01), Crenshaw

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