Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1997-12-19
1999-12-14
Webman, Edward J.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
514850, A61K 910, A61K 4730
Patent
active
060013923
ABSTRACT:
The present invention relates generally to a mixture of coated and non-coated sulfonic acid cation exchange resins (Amberlite IR69) cross-linked with about 8% divinyl benzene onto which dextromethorphan has been loaded. About 30% of the drug/resin complexes are coated with a mixture of ethyl cellulose or ethyl cellulose latexes with plasticizers and water dispersible polymers such as SURELEASE. The coating level is about 50% w/w drug. Coated and uncoated drug/resin complexes are loaded with drug to about 45% by weight drug/resin complex. The ratio of coated and uncoated drug/resin complexes is about 55/45. The particle sizes of the coated and uncoated drug/resin complexes is about 20 to about 300 and about 20 to about 250 microns, respectively.
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Dokuzovic Val
Lam Vincent
Ramsay Michael P.
Scheurer Heinrich
Wen Betty
Federman Evan J.
Warner-Lambert & Company
Webman Edward J.
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