Antitussive and mucus regulating 2-substituted thiazolidines

Details Antitussive and mucus regulating 2-substituted thiazolidines Antitussive and mucus regulating 2-substituted thiazolidines

1985-07-17

1989-01-17

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548152, 548165, 548182, 548188, 548200, 548201, 514850, A61K 31425, A61K 3138, C07C27704

Patent

active

047988983

ABSTRACT:
2-Substituted thiazolidines compounds having formula I ##STR1## wherein X is a CH.sub.2, O or S, R is hydroxy or an acyloxy, alkyloxy, alkenyloxy or alkinyloxy group, R.sub.1 is hydrogen or a group of formula ##STR2## R.sub.2 is hydrogen or a free or esterified carboxy group, R.sub.a and R.sub.b are hydrogen or methyl, p is zero or 1, R.sub.3 is a C.sub.1 -C.sub.2 alkylsulphonyl group, a phenyl or p-Cl phenyl, p-methylsulphonyl group or an acyl group; are useful as mucus regulating, antitussive and antibronchospastic agents.

REFERENCES:
patent: 3881025 (1975-04-01), Flament
patent: 4011233 (1977-03-01), Dubs et al.
patent: 4423054 (1983-12-01), Iwao et al.
patent: 4430344 (1984-02-01), Iwao et al.
patent: 4457935 (1984-07-01), Iwao et al.

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