Antitussive and mucus regulating 2-substituted thiazolidines

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

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544129, 544132, 544133, 544360, 544366, 544367, 546186, 546190, 546191, 546194, 546209, 546210, 546211, 548146, 548182, 548188, 548200, 548201, C07D, C07D27704, C07D41712

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048576433

ABSTRACT:
2-Substituted thiazolidines compounds having formula I ##STR1## wherein X is a CH.sub.2, O or S, R is hydroxy or an acyloxy, alkyloxy, alkenyloxy or alkinyloxy group, R.sub.1 is hydrogen or a group of formula ##STR2## R.sub.2 is hydrogen or a free or esterified carboxy group, R.sub.a and R.sub.b are hydrogen or methyl, p is zero or 1, R.sub.3 is hydrogen, a C.sub.1 -C.sub.2 alkylsulphonyl group, a phenyl or p-Cl phenyl, p-methylsulphonyl group or an acyl group; are useful as mucus regulating, antitussive and antibronchospastic agents.

REFERENCES:
patent: 4346088 (1982-08-01), Lang et al.
patent: 4649146 (1987-03-01), Takayo et al.
patent: 4659721 (1987-04-01), Schickaneder et al.
patent: 4732934 (1988-03-01), Abou-Gharbia et al.

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