Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from a root – bulb – tuber – corm – or...
Reexamination Certificate
2003-04-28
2009-08-04
Hoffman, Susan C (Department: 1655)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Containing or obtained from a root, bulb, tuber, corm, or...
C424S725000
Reexamination Certificate
active
07569238
ABSTRACT:
An antitussive agent. A composition for relieving, preventing and/or treating cough includes a sufficient amount of Cynanchi Atrati Radix extract as an active component. The effective Cynanchi Atrati Radix extract is prepared by extracting Cynanchi Atrati Radix with water, ethanol, hexane, ethyl acetate or a combination thereof. The crude extract can be further fractioned by ultrafiltration or reverse phase column.
REFERENCES:
patent: 1200928 (1998-12-01), None
K. Y. Lee, S. H. Sung, Y. C. Kim. New Acetylcholinesterase-Inhitbitory Pregnane Glycosides of Cynanchum atratum Roots, Helv. Chim. Acta, 86:474-483 (2003).
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http://web.archive.org/web/20021108040254/http://www.herbasin.com/database/baiwei.htm (Accessed Jan. 28, 2006).
Lin, C-C; Yen, M-H,; Wu, Y-W; Xu, G-J. Amer. J. Chinese Med., 1995, XXIII (3-4), 305-312.
Zhang, Z-X; Zhou, J; Hayashi, K.; Mitsuhashi, H. Chem. Pharm. Bull. 1985; 33(4): 1507-1514.
Day et al. (J. Nat. Products (2002), vol. 64, pp. 608-611).
Helvetica Chimica Acta (Feb. 2003), vol. 86, Table of Contents.
Chen Pin-Fen
Han Yu-Feng
Ko Feng-Nien
Lee Mai-Yu
Liu Cheng-Ko
Andrews & Kurth LLP
Chao Fei-Fei
Hoffman Susan C
Pharmaceutical Industry Technology and Development Center
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