Antitumoral d-homoestra-1,3,5 (10)-trien-3-yl 2-substituted...

Details Antitumoral d-homoestra-1,3,5 (10)-trien-3-yl 2-substituted... Antitumoral d-homoestra-1,3,5 (10)-trien-3-yl 2-substituted...

2007-07-17

2007-07-17

Powers, Fiona T. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C558S048000, C558S049000

Reexamination Certificate

active

10546230

ABSTRACT:
This invention relates to 2-substituted D-homo-estra-1,3,5(10)-trien-3-yl sulfamates of general formula I (I), in which R3 means a C1-C5-alkyl or C1-C5-alkyloxy group as well as their use for the production of a pharmaceutical agent for treating tumor diseases, which can be influenced positively by the inhibition of tubulin polymerization. The compounds according to the invention are distinguished by a D-homosubstitution. They have a special action with respect to tubulin polymerization inhibition and can be used, for example, for treating prostate cancer

REFERENCES:
patent: 6046186 (2000-04-01), Chao et al.
patent: 6583130 (2003-06-01), Schwarz et al.
patent: 6903084 (2005-06-01), Reed et al.
patent: 2004/0127473 (2004-07-01), Reed et al.
patent: 2006/0160782 (2006-07-01), Hillisch et al.
patent: 2006/0211670 (2006-09-01), Hillisch et al.
patent: WO 01/30803 (2001-05-01), None
Golub et al., Science, 286, 531-537, Oct. 15, 1999.

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