Antitumoral analogs of et-743

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C540S466000, C540S453000, C540S454000

Reexamination Certificate

active

10257857

ABSTRACT:
Antitumour compounds have the five membered fused ring ecteinascidin structure of the formula (XIV). The present compounds lack a 1,4-bridging group as found in the ecteinascidins. They have at the C-1 position a substituent selected from an optionally protected or derivatised aminomethylene group or an optionally protected or derivatised hydroxymethylene group.

REFERENCES:
patent: 5089273 (1992-02-01), Rinehart et al.
patent: 5149804 (1992-09-01), Rinehart et al.
patent: 5256663 (1993-10-01), Rinehart et al.
patent: 5478932 (1995-12-01), Rinehart et al.
patent: 5654426 (1997-08-01), Rinehart et al.
patent: 5721362 (1998-02-01), Corey et al.
patent: 5985876 (1999-11-01), Rinehart et al.
patent: 6124292 (2000-09-01), Corey
patent: 6124293 (2000-09-01), Rinehart et al.
patent: 6316214 (2001-11-01), Rinehart et al.
patent: 6348467 (2002-02-01), Corey
patent: 6686470 (2004-02-01), Danishefsky et al.
patent: 6867334 (2005-03-01), Rinehart et al.
patent: 2003/0216397 (2003-11-01), Flores et al.
patent: 2004/0002602 (2004-01-01), Francesch et al.
patent: 0 309 477 (1991-11-01), None
patent: 59-225189 (1984-12-01), None
patent: 60-84288 (1985-05-01), None
patent: WO 87/07610 (1987-12-01), None
patent: WO 92/09607 (1992-06-01), None
patent: WO 98/12198 (1998-03-01), None
patent: WO 98/46080 (1998-10-01), None
patent: WO 99/51238 (1999-10-01), None
patent: WO 99/58125 (1999-11-01), None
patent: WO 00/18233 (2000-04-01), None
patent: WO 01/8233 (2000-04-01), None
patent: WO 00/69862 (2000-11-01), None
patent: WO 01/77115 (2001-10-01), None
patent: WO 01/87895 (2001-11-01), None
Myers et al. J. Am. Chem. Soc. 121, 10828-10829, 1999.
Corey et al., Organic Letters 2(7), 993-996, 2000.
Corey et al., Organic Letters 1(1), 75-77, 1999.
Cecil Textbook of Medicine, edited by Bennet, J.C., and Plum F., 20th edition, vol. 1, 1004-1010, 1996.
Valoti et al. Clin. Cancer Res. 4(8): 1977-83, 1998.
Arai, T. et al., “The Structure of a Novel Antitumor Antibiotic, Saframycin A”,Experientia, vol. 36, pp. 1025-1027 (1980).
Arai, Tadashi et al., “Increased Production of Saframycin A and Isolation of Saframycin S”,The Journal of Antibiotics, vol. XXXIII, No. 9, pp. 951-960 (1980).
Arai, Tadashi et al., “Directd Biosynthesis of New Saframycin Derivatives with Resting Cells ofStreptomyces lavendulae”,Antimicrobial Agents and Chemotherapy, vol. 28, No. 1, pp. 5-11 (1985).
Arai, Tadashi et al., “Isoquinolineinones from Actinomycetes and Sponges”,The Alkaloids Chemistry and Pharmacology, vol. XXI, pp. 56-100 (1983).
Arai, Tadashi et al., “New Antibiotics, Safraycins, A, B, C, D and E”,The Journal of Antibiotics, vol. XXX, No. 11, pp. 1015-1018 (1977).
Arai, Tadashi et al., “Increased Production of Saframycin A and Isolation of Saframycin S”,The Journal of Antibiotics, vol. XXXIII, No. 9, pp. 951-960 (1980).
Asaoka, Takemitsu et al., “A New Saframycin, Saframycin R”,The Journal of Antibiotics, vol. XXXV, No. 12, pp. 1708-1710 (1982).
Barton, Derek H.R. et al, “Synthesis and Properties of a Series of Sterically Hindered Guanidine Bases1”,Journal of the Chemical Society Perkin Transactions I, No. 9, pp. 2085-2090 (1982).
Brown, J.M., “NCI's Anticancer Drug Screening Program May Not Be Selecting for Clinically Active Compounds,” Oncol. Res. 9(5):213-215 (1997).
Cable, Karl M. et al., “The Biosynthesis of Tuberin from Tyrosine and Glycine; Observations on the Stereochemistry Associated with the Conversion of Glycine through Methylenetetrahydrofolate into Methenyltetrahydrofolate”,Journal of the Chemical Society Perkins Transactions I, No. 7, pp. 1593-1598 (1987).
Cooper, Raymond et al., “Structure of the Quinone Antibiotic EM5519 and the Behavior of Quinones in Fast Atom Bombardment Mass Spectrometry”,The Journal of Antibiotics, vol. XXXVIII, No. 1, pp. 24-30 (1985).
Corey, E.J. et al., “Enantioselective Total Synthesis of Ecteinascidin 743”,Journal of the American Chemical Society, vol. 118, No. 38, pp. 9202-9203 (1996).
Cuevas, Carmen et al., “Synthesis of Ecteinascidin ET-743 and Phthalascidin Pt-650 from Cyanosafracin B”,Organic Letters, vol. 2, No. 16, pp. 2545-2548 (2000).
Draetta, G. and Pagano, M., “Annual Reports in Medicinal Chemistry, vol. 31,” Academic Press, San Diego, pp. 241-246 (1996).
Eckhardt, S.G. et al., “Activity of ecteinascidin, a novel marine cytotoxic, against primary human tumor colony-forming units”,Proceedings of the American Association for Cancer Research, vol. 37, #2791, pp. 409 (1996).
Faircloth, G. et al., “Ecteinascidin-743 (ET743): in vitro (IVT) and in vivo (INV) Results in Tumor Models”,The European Journal of Cancer, vol. 32A, Supp. 1, #24 O, pp. S5 (1996).
Flam, Faye, “Chemical Prospectors Scour the Seas for Promising Drugs”,Science, vol. 266, pp. 1324-1325 (1994).
Frincke, James M. et al., “Antimicrobial Metabolites of the Sponge Reniera sp.”,Journal of the American Chemical Society, vol. 104, pp. 265-269 (1982).
Fukuyama, Tohru et al., “Total Synthesis of (±)-Saframycin A”,Journal of American Chemical Society, vol. 112, pp. 3712-3713 (1990).
Fukuyama, Tohru et al., “Stereocontrolled Total Synthesis of (±)-Saframycin B”,Journal of American Chemical Society, vol. 104, pp. 4957-4958 (1982).
Garcia-Rocha, M. et al., “Characterisation of antimitotic products from marine organisms that disorganize the microtubule network: ecteinascidin 743, isohomohalichondrin-B and LL-15”,British Journal of Cancer, vol. 73, pp. 875-883 (1996).
Goldwasser, F, et al. “Characterization of ectinascidin 743-induced DNA damages in cells”,Proceedings of the American Association for Cancer Research, vol. 39, #4066, pp. 598 (1998).
Guan, Yue et al., “Molecular and Crystal Structures of Ecteinascidins: Potent Antitumor Compounds from the Caribbean Tunicate Ecteinascidia Turbinata”,Journal of Biomolecular Structure&Dynamics, vol. 10, No. 5, pp. 793-818 (1993).
Gulavita, Nanda K., et al., “Antimicrobial Constituents of a Sponge-Nudibranch Pair from Sri Lanka”,Bioactive Compounds from Marine Organisms, Oxford & IBH Publishing Co. Pvt. Ltd., pp. 229-233 (1991).
He, Hai-yin et al., “Renieramycins E and F from the Sponge Reniera sp.: Reassignment of the Stereochemistry of the Renieramycins”,The Journal of Organic Chemistry, vol. 54, No. 24, pp. 5822-5824 (1989).
Hendriks, H.R. et al., “High antitumor activity of ET743 in human tumor xenograft models”,Proceedings of the American Association for Cancer Research, vol. 37, #2653, pp. 389 (1996).
Ikeda, Yoshifumi et al., “Safracins, New Antitumor Antiobiotics I. Producing Organism, Fermentation and Isolation”,The Journal of Antibiotics, vol. XXXVI, No. 10, pp. 1279-1283 (1983).
Ikeda, Yoshifumi et al., “Safracins, New Antitumor Antibiotics I. Producing Organism, Fermentation and Isolation”,The Journal of Antibiotics, vol. XXXVI, No. 10, pp. 1284-1289 (1983).
Koenig, Karl E., “The Applicability of Asymmetric Homogeneous Catalytic Hodrogenation”,Asymmetric Synthesis, Ed. Morrison, Academic Press, Inc., Orlando, FL, vol. 5, pp. 71 (1985).
Kofron, William G. et al., “A Convenient Method for Estimation of Alkyllithium Concentrations”,The Journal of Organic Chemistry, vol. 41, No. 10, pp. 1879-1880 (1976).
Kubo, Akinori et al., “Structure of Saframycin D, A New Dimeric Isoquinolinequinone Antibiotic”,Chem. Pharm. Bull., vol. 35, No. 1, pp. 440-442 (1987).
Kuffel, M.J. et al., “Cytochrome P450 catalyzed metabolism of Ecteinascidin 743 by rat and human liver microsomes”,Proceedings of the American Association for Cancer Research, vol. 38, #4003, pp. 596 (1997).
Ito, Yoichiro, “High-Speed Countercurrent Chromatography”,Critical Reviews in Analytical Chemistry, vol. 17, No. 1, pp. 65-143 (1986).
Lichter, W

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antitumoral analogs of et-743 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antitumoral analogs of et-743, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antitumoral analogs of et-743 will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3805716

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.