Antitumor protein hybrid and process for the preparation thereof

Details Antitumor protein hybrid and process for the preparation thereof Antitumor protein hybrid and process for the preparation thereof

1980-12-15

1983-04-05

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, 260112R, A61K 3700, C07C10352, C07G 700

Patent

active

043791450

ABSTRACT:
Antitumor protein hybrid, having a moiety consisting of the antitumor immunoglobulin and a moiety substantially consisting of the fragment A of a diphtheria toxin, which is expressed by the following formula (I):

REFERENCES:
F. L. Moolten, et al., J. National Cancer Inst., Aug. 1975, vol. 55, No. 2.
Moolten et al., J. of the National Cancer Inst., 1975, vol. 55, No. 3, pp. 709-712.
Boquet; Biochem. and Biophys. Res. Commun. 75, No. 3, 1977, 696-702.

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