Antitumor pharmaceutical composition comprising IL-6 transfected

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 44, 435325, 435366, A61K48/00

Patent

active

059025760

ABSTRACT:
An anti-tumor pharmaceutical composition includes cells into which a gene encoding human IL-6 has been inserted. A method of treatment of a patient suffering from cancer to prevent and/or inhibit the development of metastases by administering to the patient the anti-tumor pharmaceutical composition including the above mentioned cells.

REFERENCES:
patent: 5188828 (1993-02-01), Goldberg et al.
Vieweg et al (1995) Cancer Investigation 13, 193-201.
Zilberstein et al., The EMBO Journal, vol. 5, No. 10, pp. 2529-2537 (1986).
Black et al, Endocrinology, vol. 128 No. 5, pp. 2657-2659 (May 1991).
Mullen et al, Cancer Res, vol. 52, pp. 6020-6024 (Nov. 1, 1992).
Scala et al, J. Exp. Med. vol. 172 pp. 61-62 (Jul. 1990).
Mule et al., J. Exp. Med., vol. 171 pp. 629-636 (Mar. 1990).
Porgador et al., "Interleukin 6 gene transfection into Lewis lung carcinoma umor cells suppresses the malignant phenotype . . ." Cancer Research, 52:3679-3686 (1992).
Russell, SJ. "Lymphokine gene therapy for cancer" Immunotherapy Today, vol. 11, No. 6, pp. 196-200 (1990).
Revel, M., Experientia 45:549-55 (1989).
Kishimoto, T., Blood 74:1-10 (1989).
Sehgal, P., Proc. Soc. Exp. Biol. Med. 195:183-191 (1990).
Eisenbach, L., et al., Int. J. Cancer 34:567-573 (1984).
Plaksin, D., et al., Proc. Natl. Acad. Sci. USA 85:4463-4467 (1988).
Southern, P., et al., J. Mol. Appl. Genet. 1:327-341 (1982).
Watanabe, Y., et al., Proc. Natl. Acad. Sci. USA 86:9456-9460 (1989).
Gansbacher, B., et al., Cancer Res. 50:7820-7825 (1990).
Fearon, E., et al., Cell. 60:397-403 (1990).
Ley, V., et al., Eur. J. Immunol. 21:851-854 (1991).
Gansbacher, B., et al., J. Exp. Med. 172:1217-1224 (1990).
Tepper, R., et al., Cell. 57:503-512 (1989).
Chirgwin, J. et al., Biochemistry 18:5294-5298 (1979).
Ozato, K. et al., J. Immunol. 126:317-321 (1981).
Eldar H., et al., J. Biological Chemistry. 265:13290-13296 (1990).
Gilboa, E., et al., BioTechniques. 4:504-512 (1986).
Markowitz, D., et al., J. Virology 62:1120-1124 (1988).
Markowitz, D., et al., J. Virology 167:400-406 (1988).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antitumor pharmaceutical composition comprising IL-6 transfected does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antitumor pharmaceutical composition comprising IL-6 transfected, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antitumor pharmaceutical composition comprising IL-6 transfected will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-244411

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.