Antitumor peptides

Details Antitumor peptides Antitumor peptides

1995-06-07

1998-11-03

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

6 to 7 amino acid residues in defined sequence

530330, 514 16, 514 17, 514 18, A61K 3808

Patent

active

058310029

ABSTRACT:
Novel compounds of the formula

REFERENCES:
patent: 4816444 (1989-03-01), Pettit et al.
patent: 5504191 (1996-04-01), Pettit et al.
patent: 5530097 (1996-06-01), Pettit et al.
Pettit, G.R. et al., "Isolation of Dolastatins 10-15 From the Marine Mollusc Dolabella Auricularia," Tetrahedron 49(41) : 9151-9170 (1993).
Pettit, G.R. et al., The Dolastatins 20. A Convenient Synthetic Route to Dolastatin 15, Tetrahedron, 50(42) : 12097-12108 (1994).
Pettit, G.R. et al., "The Isolation and Structure of a Remarkable Marine Animal Antineoplastic Constituent: Dolastatin 10", J. Am. Chem. Soc. 109: 6883-6885 (1987).
Pettit, G.R. et al., "Isolation and Structure of the Cytostatic Linear Depsipetide Dolastatin 15", J. Org. Chem., 54: 6005-6006 (1989).
Pettit, G.R. et al., "Isolation and Structure of the Cytostatic Depsipeptide Dolastatin 13 from the Sea Hare Dolabella auricularia", J. Am. Chem. Soc., 111(13) : 5015-5017 (1989).
Pettit, G.R. et al., "Antineoplastic Agents. 220. Synthesis of Natural (-) -Dolastatin 15", J. Am. Chem. Soc., 113: 6692-6693 (1991).
Bai, R., et al., "Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects on cellcular microtubules", 1-Pharmacology Abstract 117: 103735g pg. 41 (1992).
Bai, R., et al., "Structure-Activity Studies with Chiral Isomers and with Segments of the Antimitotic Marine Peptide Dolastatin 10", Biochemical Pharmacology, 40(8) : 1859-1864 (1990).

Affiliated with

Also associated with

Rating

Antitumor peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antitumor peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antitumor peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-690242