Antitumor mitoxantrone polymeric compositions

Details Antitumor mitoxantrone polymeric compositions Antitumor mitoxantrone polymeric compositions

1993-03-25

1995-01-03

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424 7833, A61K 3174, A61K 4748

Patent

active

053784561

ABSTRACT:
An antitumor polymeric composition comprising an anthracene antitumor compound, particularly mitoxantrone, covalently conjugated to, or admixed with, a divinyl ether-maleic anhydride (MVE) copolymer and methods of treating solid tumors and inducing regression of leukemia cell growth in mammals by administering such compositions.

REFERENCES:
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patent: 4871528 (1989-10-01), Tognella et al.
Mohr et al., Canc. Res. 35: 3750-3754, Dec. 1975, "Pyran Copolymer as an Effective Adjuvant to Chemotherapy against a Murine Leukemia and Solid Tumor."
Pryzybylski et al., Canc. Treat. Reports vol. 62, No. 11, Nov. 1978, "DIVEMA-Methotrexate: Immune-Adjuvant Role of Polymeric Carriers Linked to Antitumor Agents."
Zunino et al., Canc. Treat. Reports vol. 71, No. 4, Apr. 1987, "Increased Therapeutic Efficacy and Reduced Toxicity of Doxorubicin Linked to Pyran Copolymer . . . ".
Zaharko et al., Canc. Treat. Reports, vol. 68, No. 10, Oct. 1984, "Effects of 5-Aza-2'-deoxycytidine in combination with the Biochemical Modulator . . . ".
Fung et al., JNCI. vol. 62, No. 5, May 1979, "In Vitro Inhibitory Effects of Polymer-Linked Methotrexate Derivatives on Tetrahydrofolate Dehydrogenase . . . ".
Pryzybylski et al., Makromol. Chem. 179: 1719-1733, (1978), "Syntheses and Characterization of Polymeric Derivatives of the Antitumor Agent Methotrexate."
Hirano et al., Makromol. Chem. 187: 2815-2824, (1986), "Synthesis of Antitumor-Active Conjugates of Adriamycin or Daunomycin with the Copolymer of Divinyl Ether and . . . ".
Dunn et al., Amer. Chem. Soc., ACS Symposium Series 469, 1990, Polymeric Drugs and Drug Delivery Systems.

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