Antitumor indolopyrrolocarbazole derivatives

Details Antitumor indolopyrrolocarbazole derivatives Antitumor indolopyrrolocarbazole derivatives

1998-01-07

1999-07-13

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 177, 536 187, 536 291, C07H 1702, C07H 1900, C07H 1922

Patent

active

059228601

ABSTRACT:
This invention relates to compounds of the general formula ##STR1## or pharmaceutically salts thereof, wherein R.sup.1 and R.sup.2 each represent an OH group, R.sup.1 is located at the 1- or 2-position, R.sup.2 is located at the 10- or 11-position, R.sup.2 is located at the 11-position when R.sup.1 is located at the 1-position, and R.sup.2 is located at the 10-position when R.sup.1 is located at the 2-position. The compounds of the present invention have an excellent antitumor effect and are hence useful as antitumor agents in the field of medicine.

REFERENCES:
patent: 4552842 (1985-11-01), Nettleton et al.
patent: 4785085 (1988-11-01), Kaneko et al.
patent: 4808613 (1989-02-01), Kaneko et al.
patent: 4912107 (1990-03-01), Kleinschroth et al.
patent: 4923986 (1990-05-01), Murakat et al.
patent: 5015578 (1991-05-01), Schroeder et al.
patent: 5043335 (1991-08-01), Kleinschroth et al.
patent: 5073633 (1991-12-01), Schroeder et al.
patent: 5106864 (1992-04-01), Suda et al.
patent: 5158938 (1992-10-01), Lam et al.
patent: 5227396 (1993-07-01), Laakso et al.
patent: 5326754 (1994-07-01), Lam et al.
patent: 5344823 (1994-09-01), Lam et al.
patent: 5437996 (1995-08-01), Kojiri et al.
patent: 5589365 (1996-12-01), Kojiri et al.
patent: 5591842 (1997-01-01), Kojiri et al.
patent: 5643760 (1997-07-01), Kojiri et al.
patent: 5668271 (1997-09-01), Kojiri et al.
Joyce, et al. J. Org. Chem. 52, No. 7 (1987) pp. 1177-1185.
Kaneko, et al. J. Antibiotics, vol. XL111, No. 1 (1989) pp. 125-127.
47th Japan Society of Cancer General Meeting Article (1988) pp. 12-15 with English Summary.
Kojiri, et al. J. Antibiotics, vol. 44, No. 7 (Jul. 1991) pp. 723-728.
Hughes, et al. J. Chem. Soc. Perkin Trans. 1, (1990) pp. 2475-2480.
Reynolds, et al. J. Am. Chem. Soc. 60, (Oct. 1988) pp. 2559-2561.
Bush, et al. J. Antibiotics, vol. 40, (1987) pp. 668-678.
Gallant, et al., J. Org. Chem. 1993, 58, 343-349.

Affiliated with

Also associated with

Rating

Antitumor indolopyrrolocarbazole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antitumor indolopyrrolocarbazole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antitumor indolopyrrolocarbazole derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2276576