Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1980-03-17
1981-06-30
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
536 17A, A61K 3170, C07H 1524
Patent
active
042762898
ABSTRACT:
Anthracycline glycosides of the formula I ##STR1## wherein R is hydrogen or hydroxyl and the hydrochlorides thereof, and which are useful in treating certain mammalian tumors, are prepared by condensing daunomycinone with the novel sugar, 4-O-methyl-2,3,6-trideoxy-3trifluoroacetamidoribohexopyranosyl chloride in an inert organic solvent and in the presence of a soluble silver salt and a dehydrating agent to form 3', 4' -diepi-4'-O-methyl-N-trifluoroacetyl daunorubicin, and removing the N-trifluoroacetyl group therefrom. This gives the compound wherein R is hydrogen. The former is converted to the corresponding hydroxyl compound by conventional means.
REFERENCES:
patent: 4046878 (1977-09-01), Patelli et al.
patent: 4077988 (1978-03-01), Arcamone et al.
patent: 4107423 (1978-08-01), Arcamone et al.
patent: 4183919 (1980-01-01), Cassinelle et al.
Arcamone Federico
Cassinelli Giuseppe
di Marco Aurelio
Ruggieri Daniela
Brown Johnnie R.
Farmitalia Carlo Erba S.p.A.
Hazel Blondel
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