Antitumor cyclic peroxides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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549357, A61K 3135, C07D31902

Patent

active

047313773

ABSTRACT:
This invention relates to cyclic peroxide compositions, a process of producing the compositioning and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are cyclic peroxides which are derived from marine organisms, i.e., the marine sponge Plakortis lita.

REFERENCES:
Faulkner et al., C.A., 95, 21538h, (1981).
Faulkner et al., Colloq. Int. C.N.R.S., 1979, 291, (Biol. Spongiaires), 401-6.
Wells, Tetrahedron Letters, No. 33, pp. 2637-2638, (1976).
Higgs et al., J. Org. Chem., 43, 3454, (1978).
Ravi et al., ibid., 44, 3099, (1979).
Stierle et al., ibid., 45, 3396, (1980).
Phillipson et al., JACS, 105, 7735, (1983).

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